Is short course of antimicrobial therapy for asymptomatic bacteriuria before urologic surgical procedures sufficient?

Kutlu, Selda Sayin; Aybek, Zafer; Tekin, Koray; Okke, Demet; Akalin, Serife; Altintas, Serkan; Demir, Melek
February 2012
Journal of Infection in Developing Countries;Feb2012, Vol. 6 Issue 2, p143
Academic Journal
Introduction: Duration of treatment of asymptomatic bacteriuria for patients undergoing urologic surgical procedures is undetermined. We compared the efficacy of long- versus short-course antimicrobial treatment in patients with asymptomatic bacteriuria undergoing urologic surgical procedures. Methodology: Patients were divided into two groups according to duration of antimicrobial treatment. Group A patients received a single dose of an appropriate antibiotic, determined by antimicrobial sensitivity testing, 30 to 60 minutes before the surgical procedure. If a urinary catheter was placed postoperatively, a second dose was given following the recommended dose interval. Group B patients received antimicrobial treatment prior to surgery at least until patient urine became sterile. All patients were monitored for signs and symptoms of septicemia following surgical procedures. Results: None of the patients enrolled in the study developed infectious complications such as sepsis or upper urinary tract infection. In group A, 31 patients were treated with antimicrobials before 39 urological procedures. In group B, the mean treatment time for 28 patients before 30 urological procedures was 8.03 ± 3.86 days. There were also significant differences in length of stay and the cost of antimicrobial therapy between the groups (P < 0.0001). Isolation of an increased number of resistant microorganisms was associated with long course therapy in group B. Conclusions: Short course therapy protocol may be a practical, simple approach for antibiotic use; it decreases hospital stays, eliminates delayed procedure times, lowers the economic cost of antimicrobials and lessens the chance of super infection with and spread of antimicrobial resistant microorganisms.


Related Articles

  • Empirical Treatment of Community-Acquired Pneumonia and the Development of Fluoroquinolone-Resistant Tuberculosis. Long, Richard; Huey Chong; Hoeppner, Vernon; Shanmuganathan, Hareishun; Kowalewska-Grochowska, Kinga; Shandro, Cary; Manfreda, Jure; Senthilselvan, Ambikaipakan; Elzainy, Abeer; Marrie, Thomas // Clinical Infectious Diseases;5/15/2009, Vol. 48 Issue 10, p1354 

    Background. Fluoroquinolone (FLQ) antibiotics are not uncommonly prescribed for community-acquired pneumonia that is later proven to be pulmonary tuberculosis (TB). Such FLQ monotherapy may result in FLQ-resistant pulmonary TB. Methods. To assess outpatient FLQ use by patients with...

  • Microbial and Resistance Profile in Isolate from Adult Sepsis Patients: An Observational Study at an Indonesian Private Hospital during 2009-2012. Pradipta, Ivan S.; Sandiana, Ajeng T.; Halimah, Eli; Diantini, Ajeng; Lestari, Keri; Abdulah, Rizky // International Journal of Pharmaceutical Sciences Review & Resear;Mar/Apr2013, Vol. 19 Issue 2, p24 

    Sepsis is a systemic infection with a high mortality rate. The common pathogen that is found in sepsis is a bacterial pathogen, therefore, appropriateness in antibiotic use is very important to decrease the mortality and morbiditys rate in patients with sepsis. The selection of antibiotics...

  • The microbes strike back. McGeer, Allison J.; Low, Donald E. // CMAJ: Canadian Medical Association Journal;12/15/97, Vol. 157 Issue 12, p1703 

    Describes issues related to the causes and prevalence of antimicrobial resistance. Such resistance a growing global problem; Reasons for resistance; Antimicrobial resistant pathogens in Canada mainly methicillin resistance in S. aureus infection (MRSA) and vancomycin-resistant enterococci...

  • Consumer Antibacterial Soaps: Effective or Just Risky? Aiello, Allison E.; Larson, Elaine L.; Levy, Stuart B. // Clinical Infectious Diseases;9/1/2007 Supplement, Vol. 45, pS137 

    Background. Much has been written recently about the potential hazards versus benefits of antibacterial (biocide)—containing soaps. The purpose of this systematic literature review was to assess the studies that have examined the efficacy of products containing triclosan, compared with...

  • Antibiotics: Dos and Don'ts. Etingin, Orli R. // Women's Health Advisor;Sep2012, Vol. 16 Issue 9, p1 

    In this article, the author discusses the positive and negative aspects associated with the use of antibiotics and antimicrobial agents. She opines that overuse of antibiotics has led to the development of resistant bacteria that can grow in the presence of antibiotics and this can lead to...

  • Dalbavancin A novel long-acting lipoglycopeptide antibiotic. Blostica, Thomas M.; Michael E. Klepser // Formulary;Feb2006, Vol. 41 Issue 2, p59 

    Dalbavancin (Pfizer) is a new lipoglycopeptide antibiotic in phase 3 trials for the treatment of resistant grann-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). This agent exerts its bactericidal activity by binding to...

  • Drug-resistant pneumococcal pneumonia: clinical relevance and approach to management. Fuller, J.; McGeer, A.; Low, D. // European Journal of Clinical Microbiology & Infectious Diseases;Dec2005, Vol. 24 Issue 12, p780 

    Community-acquired pneumonia is the most common infectious disease that causes death, with Streptococcus pneumoniae remaining the leading causative pathogen. The worldwide incidence of infections caused by pneumococci resistant to penicillin, macrolides, and other antimicrobial agents has...

  • Pharmacy and therapeutics committees in Brazil: lagging behind international standards. Cruz Marques, Dirce; Zucchi, Paola // Revista Panamericana de Salud Publica;Jan2006, Vol. 19 Issue 1, p58 

    The inadequate use of drugs leads to lack of therapeutic efficacy, adverse reactions, side effects, preventable drug interactions, increased bacterial resistance to antibiotics, and wasted resources. Changing this scenario is one of the most complex challenges facing health systems today. One...

  • ENTEROCOCCAL RESISTANCE -- AN OVERVIEW. Marothi, Y. A.; Agnihotri, H.; Dubey, D. // Indian Journal of Medical Microbiology;Oct2005, Vol. 23 Issue 4, p214 

    Nosocomial acquisition of microorganisms resistant to multiple antibiotics represents a threat to patient safety. Here, we review the antimicrobial resistance in Enterococcus, which makes it important nosocomial pathogen. The emergence of enterococci with acquired resistance to vancomycin has...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics