Formulation and evaluation of lovastatin fast dissolving tablets using newer super disintegrants

Vidyadhara, S.; Reddy, G. V. Ramana; Ramu, A.; Chandana, P.
June 2011
Journal of Pharmacy Research;Jun2011, Vol. 4 Issue 6, p1762
Academic Journal
The objective of this study was to improve the solubility and dissolution rate of a poorly water-soluble hydrophobic drug, Lovastatin with Polyethylene glycol-6000 as a carrier, by solid dispersion techniques. The dispersions were prepared by employing different techniques such as physical mixing, fusion method and co-grinding methods The prepared solid dispersions were compressed into tablets by direct compression along with solubility enhancing excipients like novel super-disintegrates such as croscarmellose sodium, crospovidone, pregelatinized starch, etc. The solid dispersions of Lovastatin with PEG-6000 were found to release drug faster than the pure drug in dissolution media. The rapid release of poorly soluble Lovastatin from solid dispersions was influenced by the proportion and physicochemical properties of polymer and the method employed for their preparations. Among the three methods employed fusion method was found to be suitable for improving the dissolution rate of Lovastatin. The dispersions prepared by fusion method were further compressed as tablets with various super disintegrants. Order of disintegration of various tablet preparations with super disintegrants was found to be Crospovidone > Pregelatinised starch > Croscarmellose. When compared to marketed formulation the disintegration rate and dissolution rate of prepared tablets were found to be rapid.


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