TITLE

Establishment of Pharmacokinetic Parameters for the Herbal Drug Containing Forskolin

AUTHOR(S)
Sangeetha, S.; Samanta, M. K.; Manjunatha, N.; Tiwari, Sindhu
PUB. DATE
July 2011
SOURCE
Journal of Pharmacy Research;Jul2011, Vol. 4 Issue 7, p2303
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The rationale of this project work was to formulate oral herbal tablets of Coleus forskohlii extract and also with pure forskolin, further to determine the pharmacokinetic profile for both.The concentration of forskolin in Coleus forskohlii extract was estimated by HPTLC with comparison to pure form. Tablets were prepared for extract and synthetic form through direct compression technique by varying the process and formulation parameters. The pre and post compression parameters were evaluated for the formulated batches. Rabbit models of either sex were selected for pharmacokinetic studies.The tablets formulated possessed ideal physicochemical and pharmaceutical properties. The invitro release studies showed that it followed first order release kinetics. Even though there was no significance difference with p value between the pharmacokinetic data obtained for pure and extract of forskolin tablets, the absorption was slightly increased in case of extract. Administration of drug in the extract form at the dose interval and size as that of synergistic or isolated may serve the pharmacological effect with minimized cost value.
ACCESSION #
74427504

 

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