TITLE

Antagonistic Regulation of Apoptosis and Differentiation by the Cut Transcription Factor Represents a Tumor-Suppressing Mechanism in Drosophila

AUTHOR(S)
Zongzhao Zhai; Nati Ha; Papagiannouli, Fani; Hamacher-Brady, Anne; Brady, Nathan; Sorge, Sebastian; Bezdan, Daniela; Lohmann, Ingrid
PUB. DATE
March 2012
SOURCE
PLoS Genetics;Mar2012, Vol. 8 Issue 3, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Apoptosis is essential to prevent oncogenic transformation by triggering self-destruction of harmful cells, including those unable to differentiate. However, the mechanisms linking impaired cell differentiation and apoptosis during development and disease are not well understood. Here we report that the Drosophila transcription factor Cut coordinately controls differentiation and repression of apoptosis via direct regulation of the pro-apoptotic gene reaper. We also demonstrate that this regulatory circuit acts in diverse cell lineages to remove uncommitted precursor cells in status nascendi and thereby interferes with their potential to develop into cancer cells. Consistent with the role of Cut homologues in controlling cell death in vertebrates, we find repression of apoptosis regulators by Cux1 in human cancer cells. Finally, we present evidence that suggests that other lineage-restricted specification factors employ a similar mechanism to put the brakes on the oncogenic process.
ACCESSION #
74426103

Tags: APOPTOSIS;  TRANSCRIPTION factors;  CANCER cells;  CELL differentiation;  DROSOPHILA

 

Related Articles

  • Synergic effect of a-tocopherol and naringenin in transglutaminase-induced differentiation of human prostate cancer cells. Torricelli, Piera; Ricci, Pasquale; Provenzano, Bruno; Lentini, Alessandro; Tabolacci, Claudio // Amino Acids;Nov2011, Vol. 41 Issue 5, p1207 

    Prostate cancer is the second most common cancer in men worldwide. Its prevention and treatment remain a challenge to clinicians. Thus, there is an urgent need to discover novel, less toxic, and more effective therapies for patients. Many vitamins and related chemicals, including vitamin E,...

  • Tumorigenesis: Cut here for differentiation. McCarthy, Nicola // Nature Reviews Cancer;May2012, Vol. 12 Issue 5, p320 

    The article discusses research being done on tumorigenesis. It references the study "Antagonistic regulation of apoptosis and differentiation by the Cut transcription factor represents a tumour suppressing mechanism in Drosophila," by Z. Zhai and colleagues in the 2012 issue of the journal "PLoS...

  • Hand is a direct target of the forkhead transcription factor Biniou during Drosophila visceral mesoderm differentiation. Popichenko, Dmitry; Sellin, Julia; Bartkuhn, Marek; Paululat, Achim // BMC Developmental Biology;2007, Vol. 7, p1 

    Background: The visceral trunk mesoderm in Drosophila melanogaster develops under inductive signals from the ectoderm. This leads to the activation of the key regulators Tinman, Bagpipe and Biniou that are crucial for specification of the circular visceral muscles. How further differentiation is...

  • MicroRNAs: novel biomarkers for gastrointestinal carcinomas. Xie, Li; Qian, Xiaoping; Liu, Baorui // Molecular & Cellular Biochemistry;Aug2010, Vol. 341 Issue 1/2, p291 

    MicroRNAs (miRNAs) are a class of non-coding small RNAs. They play an important role as a post-transcriptional regulator in the protein synthesis and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. miRNAs give us a new perspective to understand...

  • CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. Ripka, S.; Neesse, A.; Riedel, J.; Bug, E.; Aigner, A.; Poulsom, R.; Fulda, S.; Neoptolemos, J.; Greenhalf, W.; Barth, P.; Gress, T. M.; Michl, P. // Gut;Aug2010, Vol. 59 Issue 8, p1101 

    BACKGROUND AND AIMS: The transcription factor CUX1 is known as a regulator of cell differentiation and cell cycle progression. Previously, CUX1 was identified as a modulator of invasiveness in various cancers. Based on expression profiles suggesting a role for CUX1 in mediating chemoresistance,...

  • NFATc1 Regulation of TRAIL Expression in Human Intestinal Cells. Qingding Wang; Yuning Zhou; Weiss, Heidi L.; Chi-Wing Chow; Evers, B. Mark // PLoS ONE;2011, Vol. 6 Issue 5, p1 

    TNF-related apoptosis-inducing ligand (TRAIL; Apo2) has been shown to promote intestinal cell differentiation. Nuclear factor of activated T cells (NFAT) participates in the regulation of a variety of cellular processes, including differentiation. Here, we examined the role of NFAT in the...

  • Regulation of PBX3 expression by androgen and Let-7d in prostate cancer. Ramberg, H�kon; Alshbib, Ayham; Berge, Viktor; Svindland, Aud; Task�n, Kristin Austlid // Molecular Cancer;2011, Vol. 10 Issue 1, p50 

    Background: The pre-leukemia transcription factor 3 (PBX) is part of the PBX family of transcription factors, which is known to regulate genes involved in differentiation of urogenital organs and steroidogenesis. This is of interest with regard to prostate cancer progression as regulation of...

  • Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. Tabuse, Masanao; Ohta, Shigeki; Ohashi, Yohei; Fukaya, Raita; Misawa, Aya; Yoshida, Kazunari; Kawase, Takeshi; Saya, Hideyuki; Thirant, C�cile; Chneiweiss, H�rve; Matsuzaki, Yumi; Okano, Hideyuki; Kawakami, Yutaka; Toda, Masahiro // Molecular Cancer;2011, Vol. 10 Issue 1, p60 

    Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. They also behave as oncogenes in some malignancies. Results: In this study, we found high expression of the HOXD9 gene...

  • The Nuclear Factor Kappa-B Signaling Pathway as a Therapeutic Target Against Thyroid Cancers. Li, Xinying; Abdel-Mageed, Asim B.; Mondal, Debasis; Kandil, Emad // Thyroid;Feb2013, Vol. 23 Issue 2, p209 

    Background: The nuclear factor kappa-B (NF-?B) proteins, a family of transcription factors found virtually in all cells, are known to play crucial roles in the growth of a number of human malignancies. The ability of NF-?B to target a large number of genes that regulate cell proliferation,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics