TITLE

HPLC Method development for Simultaneous Estimation of Pyridoxine, Thiamine, Paracetamol and Ibuprofen in Tablets

AUTHOR(S)
Basha, D. Peer; Teja, Bulusu Bhanu; Kumar, Katikala. Prasanth; Murthy, P. V. S. N.; Raghunath, T. Murali; Sastry, J. P. V. S. B. S. R.; Srikanth, A. U.; Subbarao, M.
PUB. DATE
May 2011
SOURCE
Journal of Pharmacy Research;May2011, Vol. 4 Issue 5, p1584
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A simple, selective, accurate high Performance Liquid Chromatographic (HPLC) method was developed and validated for the analysis of Thiamine, Pyridoxine, Paracetamol and Ibuprofen in combined form. Chromatographic separation achieved by gradient on a C8 column. The retention time of Pyridoxine, Thiamine, Paracetamol and Ibuprofen was 5.22, 6.58, 7.40 and 11.02min respectively with in 15min run time. The developed method was validated for accuracy, linearity and solution stability. This method was developed for estimation of four drugs in combination in a single oral dosage form in a HPLC method analysis.
ACCESSION #
74388011

 

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