TITLE

The development of aceclofenac multiparticulate colon specific drug delivery using combination of time dependent polymers

AUTHOR(S)
Nicholas, Madhu E.; Panaganti, Shanker; Prabakaran, L.; Jayveera, K. N.
PUB. DATE
December 2011
SOURCE
Journal of Pharmacy Research;Dec2011, Vol. 4 Issue 12, p4380
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The purpose of this research was to develop novel colon specific drug delivery multiparticulate systems for aceclofenac using time dependent polymers, ethyl cellulose and hydroxy propyl cellulose. The pellets were evaluated for physicochemical properties, drug content, erosion characteristics and in vitro drug release studies. The amount of aceclofenac released from the ethyl cellulose, hydroxy propyl cellulose coated pellets at different time intervals was estimated by UV spectrophotometric method at 275nm. The optimized formula shown, not considerable drug release in stomach i.e 4.45%. In small intestine it was 28.6% where as in colon it was 83.64% in controlled manner. Ethyl cellulose coating prevented release of the aceclofenac in the physiological environment of stomach and small intestine depending on the proportion of hydroxy propyl cellulose coating in the formulation. The FTIR and DSC results revealed the compatability of drug with the excipients. The In-vitro dissolution studies shown that coated pellets were promising for target delivery of the drug. The findings of the present study conclusively state that coated pellets are promising for colon targeting of aceclofenac to synchronize the chronobiological symptoms for effective treatment of rheumatoid arthritis.
ACCESSION #
74296831

 

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