Liquisolid: A novel technique to enhance solubility and dissolution rate of BCS class II Pharmaceuticals

Walke, Prashant S.; Pawar, Ashish Y.; Sonawane, Deepak D.; Bhamber, Rajendra S.
November 2011
Journal of Pharmacy Research;Nov2011, Vol. 4 Issue 11, p4011
Academic Journal
Liquisoild technique is a New technique for delivery of drugs through oral route. This technique of delivering drugs is suitable mostly for lipophilic drugs and poorly water soluble drugs. This approach is suitable for immediate or sustain release formulations. Design of this technique was according to new mathematical model proposed by Spireas et al. Increasing the solubility by using a non-volatile solvent which is suitable for drug, their by dissolving the drug in the non volatile solvent and this is termed as liquid medicament . Blending the liquid medicament with mixture of carrier and coating material, liquid medicament can be converted into non adhere, dry looking powder with acceptable flow properties and compression behavior using suitable excipients and tabletting by direct compression method. . Increase in dissolution rate and in turn improvement in bioavailability is observed in case of poorly water soluble drugs. However, sustained effect is achieved in case of water soluble drugs. Liquisolid system is evaluated by flow behavior, wettability, powder bed hydrophilicity, saturation solubility, drug content, differential scanning calorimetry, Fourier transform infra red spectroscopy, powder X-ray differaction, scanning electron microscopy, invitro release and in vivo evaluation. Liquisolids serve as a better technique in the controlled release formulations of poorly water soluble drugs.


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