TITLE

Visible Spectrophotometric Method for the estimation of Amlodipine Besylate in tablet dosage forms

AUTHOR(S)
Bhargavi, P.; Chandana, B.; Lohita, M.; Ramalingam, P.; Theja, D. H. H.; Kumar, K. Vinod
PUB. DATE
November 2011
SOURCE
Journal of Pharmacy Research;Nov2011, Vol. 4 Issue 11, p4001
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Rapid and sensitive visible Spectrophotometric method has been developed for the estimation of Amlodipine Besylate in pharmaceutical formulations. The proposed method is based on the formation of green coloured complex by the use of Potassium dichromate (0.1N) and 50 % H2SO4. The formed complex shows maximum absorption at 600 nm and obeys Beer's law in the concentration range of 0.7- 7µg/ml. The developed method has been statistically validated for application in pharmaceutical quality control laboratory and shows interday and intraday precision of 1.8 % and 1.7% respectively. The recovery was in between 99.98- 100% and results for Sandell's sensitivity and limit of detection were 0.00666 µg/cm3 and 0.32 µg/ml respectively.
ACCESSION #
74292648

 

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