TITLE

Phytochemical Studies and In vitro Cytotoxicity Screening of Piper betle Leaves Extracts

AUTHOR(S)
Chaurasia, Sundeep; Kulkarni, Giriraj Tirupatirao; Shetty, Laxmi Narayan; Mishra, Brahmeshwar
PUB. DATE
November 2011
SOURCE
Journal of Pharmacy Research;Nov2011, Vol. 4 Issue 11, p4187
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Piper betle leaves Linn. (Family: Piperaceae) can be found in ancient Sanskrit texts, including Charaka, Susruta Samhita and Astanga Hradayam. Piper betle leaves have been used in Chinese and Indian folk medicine for centuries, and recently been proposed to be used as a chemopreventive agent because of its antioxidant activity. In the present paper, Piper betle leaves were standardized for stomatal index, vein islet, vein termination numbers, palisade ratio, Ultra Violet fluorescence and different ash values. The Piper betle leaves are earlier reported to possess anticancer potential. Hence, the aqueous extract of the leaves was subjected to cytotoxicity studies on Hep-2 cell line using Microculture Tetrazolium and Sulphorhodamine B assays. The mean CTC50 was found to be 96.25 µg/ ml, which proved the potent cytotoxicity and hence, the probable anticancer property of the selected extracts.
ACCESSION #
74292574

 

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