TITLE

Acute toxicity and Diuretic studies of leaves of Cassia occidentalis Linn

AUTHOR(S)
Arun, Mittal; Sushma, Aggarwal; Kumar, Gupta Anil; Satish, Sardana
PUB. DATE
September 2011
SOURCE
Journal of Pharmacy Research;Sep2011, Vol. 4 Issue 9, p3042
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cassia occidentalis is used in the traditional medicine system as diuretic. In the present studyacute toxicity and diuretic activity of ethanolic extract of Cassia occidentalis (200 & 400mg/kg b.w, p.o) was evaluated on wistar strain albino rats. The activity was compared with furosemide (4 mg/kg b.w, I p) as standard drug. Results revealed that the extract acts as diuretic because of increased urinary electrolyte concentration with significant increase in the urinary output. The increase in the ratio of concentration of excreted sodium and potassium ion for the test extracts, compared to control, indicates that the extracts increases potassium ion excretion to a greater extent than sodium ion, which is very essential quality of a good diuretic.
ACCESSION #
74266189

 

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