TITLE

Neurogenic differentiation of amniotic fluid stem cells

AUTHOR(S)
Rosner, M.; Mikula, M.; Preitschopf, A.; Feichtinger, M.; Schipany, K.; Hengstschläger, M.
PUB. DATE
May 2012
SOURCE
Amino Acids;May2012, Vol. 42 Issue 5, p1591
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In 2003, human amniotic fluid has been shown to contain stem cells expressing Oct-4, a marker for pluripotency. This finding initiated a rapidly growing and very promising new stem cell research field. Since then, amniotic fluid stem (AFS) cells have been demonstrated to harbour the potential to differentiate into any of the three germ layers and to form three-dimensional aggregates, so-called embryoid bodies, known as the principal step in the differentiation of pluripotent stem cells. Marker selection and minimal dilution approaches allow the establishment of monoclonal AFS cell lineages with high proliferation potential. AFS cells have a lower risk for tumour development and do not raise the ethical issues of embryonic stem cells. Compared to induced pluripotent stem cells, AFS cells do not need exogenic treatment to induce pluripotency, are chromosomal stable and do not harbour the epigenetic memory and accumulated somatic mutations of specific differentiated source cells. Compared to adult stem cells, AFS can be grown in larger quantities and show higher differentiation potential. Accordingly, in the recent past, AFS became increasingly accepted as an optimal tool for basic research and probably also for specific cell-based therapies. Here, we review the current knowledge on the neurogenic differentiation potential of AFS cells.
ACCESSION #
74220363

 

Related Articles

  • Stem Cells from Amniotic Fluid: Reprogrammed Amniotic Fluid Cells Can Generate All Types of Body Cells.  // Journal of Biological Sciences;2011, Vol. 11 Issue 1, p72 

    No abstract available.

  • Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Berge, Derk ten; Kurek, Dorota; Blauwkamp, Tim; Koole, Wouter; Maas, Alex; Eroglu, Elif; Siu, Ronald K.; Nusse, Roel // Nature Cell Biology;Sep2011, Vol. 13 Issue 9, p1070 

    Pluripotent stem cells exist in naive and primed states, epitomized by mouse embryonic stem cells (ESCs) and the developmentally more advanced epiblast stem cells (EpiSCs; ref. ). In the naive state of ESCs, the genome has an unusual open conformation and possesses a minimum of repressive...

  • Epigenetic Control of Embryonic Stem Cell Differentiation. Armstrong, Lyle // Stem Cell Reviews & Reports;Mar2012, Vol. 8 Issue 1, p67 

    Pluripotent embryonic stem cells can give rise to almost all somatic cell types but this characteristic requires precise control of their gene expression patterns. The necessity of keeping the entire genome 'poised' to enter into any of a number of developmental possibilities requires a unique...

  • Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells. El-Mounayri, Omar; Mihic, Anton; Shikatani, Eric A.; Gagliardi, Mark; Steinbach, Sarah K.; Dubois, Nicole; DaCosta, Ralph; Li, Ren-Ke; Keller, Gordon; Husain, Mansoor // Cardiovascular Research;Apr2013, Vol. 98 Issue 1, p125 

    Aims Despite the diverse developmental origins of vascular smooth muscle cells (VSMCs), recent attempts to generate VSMCs from human embryonic stem cells (hESCs) differentiated along various lineages did not yield distinct cell phenotypes. The aim of this study was to derive and characterize...

  • Identification and Characterisation of the Early Differentiating Cells in Neural Differentiation of Human Embryonic Stem Cells. Noisa, Parinya; Selvee Ramasamy, Thamil; Lamont, Fiona R.; Yu, Jason S. L.; Sheldon, Michael J.; Russell, Alison; Xin Jin; Wei Cui // PLoS ONE;May2012, Vol. 7 Issue 5, p1 

    One of the challenges in studying early differentiation of human embryonic stem cells (hESCs) is being able to discriminate the initial differentiated cells from the original pluripotent stem cells and their committed progenies. It remains unclear how a pluripotent stem cell becomes a...

  • Pluripotent stem cells as a model to study non-coding RNAs function in human neurogenesis. Benchoua, Alexandra; Peschanski, Marc // Frontiers in Cellular Neuroscience;Aug2013, Vol. 7, p1 

    As fine regulators of gene expression, non-coding RNAs, and more particularly micro-RNAs (miRNAs), have emerged as key players in the development of the nervous system. In vivo experiments manipulating miRNAs expression as neurogenesis proceeds are very challenging in the mammalian embryo and...

  • Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation. Miyamoto, Tadashi; Furusawa, Chikara; Kaneko, Kunihiko // PLoS Computational Biology;8/26/2015, Vol. 11 Issue 8, p1 

    Embryonic stem cells exhibit pluripotency: they can differentiate into all types of somatic cells. Pluripotent genes such as Oct4 and Nanog are activated in the pluripotent state, and their expression decreases during cell differentiation. Inversely, expression of differentiation genes such as...

  • Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells. Liu, Haisong; Yang, Huan; Zhu, Dicong; Sui, Xin; Li, Juan; Liang, Zhen; Xu, Lei; Chen, Zeyu; Yao, Anzhi; Zhang, Long; Zhang, Xi; Yi, Xing; Liu, Meng; Xu, Shiqing; Zhang, Wenjian; Lin, Hua; Xie, Lan; Lou, Jinning; Zhang, Yong; Xi, Jianzhong // Cell Research;Oct2014, Vol. 24 Issue 10, p1181 

    The applications of human pluripotent stem cell (hPSC)-derived cells in regenerative medicine has encountered a long-standing challenge: how can we efficiently obtain mature cell types from hPSCs? Attempts to address this problem are hindered by the complexity of controlling cell fate commitment...

  • Cell Pluripotency Levels Associated with Imprinted Genes in Human. Yuan, Liyun; Tang, Xiaoyan; Zhang, Binyan; Ding, Guohui // Computational & Mathematical Methods in Medicine;10/4/2015, Vol. 2015, p1 

    Pluripotent stem cells are exhibited similarly in the morphology, gene expression, growth properties, and epigenetic modification with embryonic stem cells (ESCs). However, it is still controversial that the pluripotency of induced pluripotent stem cell (iPSC) is much inferior to ESC, and the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics