Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

January 2012
Breast Cancer Research;2012, Vol. 14 Issue 1, p3121
Academic Journal
The article presents information on a research that analyzes the role of single nucleotide polymorphisms (SNPs) in breast cancer risk for BRCA1 and BRCA2 carriers. The relation of eight loci to breast cancer risk for BRCA1 and BRCA2 mutation carriers are not known so the researchers genotyped these SNPs in 12,599 BRCA1 and 7,132 BRCA2 mutation carriers to examine its relationship. The study was done to improve the understanding of the disease etiology in BRCA1 and BRCA2 mutation carriers.


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