TITLE

Targeting Tat and IFNα as a Therapeutic AIDS Vaccine

AUTHOR(S)
Gallo, R.C.; Burny, A.; Zagury, D.
PUB. DATE
September 2002
SOURCE
DNA & Cell Biology;Sep2002, Vol. 21 Issue 9, p611
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Evolution to AIDS is characterized by a progressive cellular immune suppression. Although there is substantial evidence for several mechanisms involved in disrupting the immune response by induction of apoptosis in responder cells by contact with infected cells, we propose that humoral factors also play a role, and that one such factor is the extracellular form of the human immunodeficiency virus (HIV)-1 Tat protein and another is IFNα. Both Tat and interferon-α (IFNα) inhibit antigen-stimulate T-cell proliferation, and specific anti-Tat and/or anti-IFNα Abs prevent generation of HIV-1-induced suppressor cells. We propose that high titer anti-Tat and/or anti-IFNα Abs, neutralizing extracellular Tat, and/or IFNα, induced by vaccines described here, antagonize HIV-1-induced immunosuppression. Innocuous vaccines were prepared by using inactivated but immunogenic Tat (Toxoid) and inactivated and immunogenic IFNα (kinoid) derivatives. Both Tat Toxoid and IFNα kinoid were well tolerated and elicited specific neutralizing antibodies (Abs) in mice, monkeys, and seronegative and HIV-1-infected individuals.
ACCESSION #
7411863

 

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