Design and In Vivo Immunogenicity of a Polyvalent Vaccine Based on SIVmac Regulatory Genes
- HIV-1 Nef protein: An invitation to a kill. Cullen, Bryan R. // Nature Medicine;Sep99, Vol. 5 Issue 9, p985
New evidence demonstrates that HIV-1 Nef production by macrophages not only attracts T-lymphocytes but also renders them permissive for HIV-1 infection (pages 997?1003).
- Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution. Das, Atze T.; Klaver, Bep; Centlivre, Mireille; Harwig, Alex; Ooms, Marcel; Page, Mark; Almond, Neil; Fang Yuan; Piatak Jr., Mike; Lifson, Jeffrey D.; Berkhout, Ben // Retrovirology;2008, Vol. 5, Special section p1
Background: Vaccination of macaques with live attenuated simian immunodeficiency virus (SIV) provides significant protection against the wild-type virus. The use of a live attenuated human immunodeficiency virus (HIV) as AIDS vaccine in humans is however considered unsafe because of the risk...
- Simian Virus Large T Antigen Interacts with the N-Terminal Domain of the 70 kD Subunit of Replication Protein A in the Same Mode as Multiple DNA Damage Response Factors. Ning, Boting; Feldkamp, Michael D.; Cortez, David; Chazin, Walter J.; Friedman, Katherine L.; Fanning, Ellen // PLoS ONE;Feb2015, Vol. 10 Issue 2, p1
Simian virus 40 (SV40) serves as an important model organism for studying eukaryotic DNA replication. Its helicase, Large T-antigen (Tag), is a multi-functional protein that interacts with multiple host proteins, including the ubiquitous ssDNA binding protein Replication Protein A (RPA). Tag...
- Pirate Primates in Uncharted Waters: Lymphocyte Transfers in Unrelated, MHC-Matched Macaques. Burwitz, Benjamin J.; Greene, Justin M.; O'Connor, David H. // Current HIV Research;Jan2009, Vol. 7 Issue 1, p51
An HIV vaccine remains elusive despite the concerted efforts of investigators and clinicians over the past two decades. Animal models are regularly used to obtain new insights on disease pathogenesis and have become invaluable tools in the translation of treatments from basic research...
- Infection of mesangial cells with HIV and SIV: Identification of GPR1 as a coreceptor. Tokizawa, Shigemi; Shimizu, Nobuaki; Hui-Yu, Liu; Deyu, Fang; Haraguchi, Yuji; Oite, Takashi; Hoshino, Hiroo // Kidney International;Aug2000, Vol. 58 Issue 2, p607
Infection of mesangial cells with HIV and SIV: Identification of GPR1 as a coreceptor. Background. Mesangial cells are an important component of the glomerulus. Dysfunction of mesangial cells is thought to be involved in the development of human immunodeficiency virus type 1 (HIV-1)-associated...
- Will wild chimp pee tell all about HIV? Brown, Phyllida // New Scientist;09/11/99, Vol. 163 Issue 2203, p25
Focuses on a report in the September 4, 1999 issue of the `New Scientist,' on research into the origins of the HIV through the construction of a family tree fir chimpanzee forms of the simian immunodeficiency virus (SIV). Rationale behind the study of SIV; Relationship between SIV and HIV.
- Good news on AIDS. Costello, Emily // Science World;2/9/96, Vol. 52 Issue 9, p6
Reports on two discoveries in the battle against AIDS. Persistence of good health of people in Australia for 14 years after being infected with HIV; Possible use of genetically defective strain of HIV as vaccine; Effectiveness of a drug in stopping simian immuno-deficiency virus (SIV);...
- Animal Models Used for the Evaluation of Antiretroviral Therapies. P. Dias, Andreia S.; Bester, Megan J.; Britz, Rozane F.; Apostolides, Zeno // Current HIV Research;Oct2006, Vol. 4 Issue 4, p431
Several animal models for the study of HIV/AIDS have been established and characterized and have been widely used to study the pathogenesis of HIV/AIDS as well as vaccine development. The purpose of this study was to review the literature and identify the animal models most frequently used for...
- Researchers track ancestry of HIV to monkey meat. // Gay & Lesbian Times;6/19/2003, Issue 808, p28
Reports that the ancestry of the HIV virus has been traced to two strains of virus found in monkeys in Africa. Ways by which the viruses have been passed into chimpanzees; Genetic pattern of the simian immunodeficiency virus.