Cytotoxic T-Lymphocyte Escape Monitoring in Simian Immunodeficiency Virus Vaccine Challenge Studies

O'Connor, David H.; Allen, Todd M.; Watkins, David I.
September 2002
DNA & Cell Biology;Sep2002, Vol. 21 Issue 9, p659
Academic Journal
Several vaccine studies have ameliorated disease progression in simian–human immunodeficiency virus (SHIV) infections. The successes of these vaccines have been largely attributed to protective effects of cytotoxic T-lymphocyte (CTL) responses, although the precise correlates of immune protection remain poorly defined. It is now well established that vigorous CTL and antibody responses can rapidly select for viral escape variants after HIV and SIV infection. Here we suggest that viral variation analyses should be performed on viruses derived from vaccinated, SIV-, or SHIV-challenged animals as a routine component of vaccine evaluation to determine the contribution of immune responses to the success (or failure) of the vaccine regimen. To illustrate the importance of escape analysis, we show that rapid emergence of escape variants postchallenge contributed to the failure of a DNA prime/MVA boost vaccine regimen encoding SIV Tat.


Related Articles

  • MUCOSAL VACCINES TO INDUCE CELLULAR IMMUNITY AGAINST HIV AND OTHER VIRAL INFECTIONS. Berzofsky, Jay A.; Belyakov, Igor M. // Vaccines: Preventing Disease & Protecting Health;2004, p223 

    Information on the vaccine strategies being tested in the U.S. to induce cellular immunity against HIV and other viral infections from a chapter of the book "Vaccines: Preventing Disease and Protecting Health" is presented. It offers physiological information on the mucosal immune system,...

  • Suppression of Th1 and Th17, but not Th2, responses in a CD8+ T cell-mediated model of oral tolerance. Arnaboldi, P. M.; Roth-Walter, F.; Mayer, L. // Mucosal Immunology (1933-0219);Sep2009, Vol. 2 Issue 5, p427 

    The role of CD8+ T cells in oral tolerance remains unclear. To address this, we developed a model to induce CD8+ Tregs by feeding the major histocompatibility complex class I immunodominant epitope of OVA, OVA(257–264). OVA(257–264) feeding induced tolerance similar to that...

  • Swine virus-specific cytotoxic cells producing IFNγ under different conditions of virus antigenic stimulation. Ferrari, L.; De Angelis, E.; Martelli, P.; Borghetti, P. // Veterinary Research Communications;Jun2010, Vol. 34, p63 

    Flow cytometry is a useful tool to determine both the phenotype and function of immune cells during vaccination and viral infection. Since cytokine release is a hallmark of cell activation, detection of intracellular interferon (IFN)γ in cytotoxic CD8α+ cells under physiological conditions...

  • Cytotoxic T Lymphocytes. Lawrence, B. Paige; Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p184 

    The article offers information about cytotoxic T lymphocytes (CTL). It refers to T cells that, upon contact with antigen-bearing cells, directly kill target cells which are usually infected with virus. Thus, it plays an important role in host defense against pathogens, detect and destroy tumor...

  • Induction/Engineering, Detection, Selection, and Expansion of Clinical-Grade Human Antigen-Specific CD8+ Cytotoxic T Cell Clones for Adoptive Immunotherapy. Jeras, Matjaž; Bricl, Irena; Robert Zorec; Švajger, Urban // Journal of Biomedicine & Biotechnology;2010, p1 

    Adoptive transfer of effector antigen-specific immune cells is becoming a promising treatment option in allogeneic transplantation, infectious diseases, cancer, and autoimmune disorders. Within this context, the important role of CD8+ cytotoxic T cells (CTLs) is objective of intensive studies...

  • HIV-1 Group M Conserved Elements Vaccine. Rolland, Morgane; Nickle, David C.; Mullins, James I. // PLoS Pathogens;Nov2007, Vol. 3 Issue 11, pe157 

    The authors propose an alternative HIV-1 vaccine design that deliberately includes viral segments conserved across the entire main group or M group of HIV-1 strains and excludes variable segments. According to them, the ideal way to cope with HIV-1 diversity is to avoid it and a vaccine should...

  • IL-2, IL-7 and IL-15 as Immuno-Modulators During SIV/HIV Vaccination and Treatment. Leone, Amanda; Picker, Louis J.; Sodora, Donald L. // Current HIV Research;Jan2009, Vol. 7 Issue 1, p83 

    While highly active antiretroviral therapy (HAART) regimens have proven to be effective in controlling active HIV replication, complete recovery of CD4+ T cells does not always occur, even among patients with high level virologic control. Recent advances in understanding the biology of T cell...

  • NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation. Meinke, Stephan; Watzl, Carsten // Frontiers in Immunology;Jan2013, Vol. 4, p1 

    2B4 (CD244) and NK-T-B-antigen (NTB-A, CD352) are activating receptors on human natural killer (NK) cells and belong to the family of signaling lymphocyte activation molecule (SLAM)-related receptors (SRR). Engagement of these receptors leads to phosphorylation of their cytoplasmic tails and...

  • The role of BMT in childhood histiocytoses. Caselli, D.; Aricò, M. // Bone Marrow Transplantation;Jun2008 Supplement, Vol. 41, pS8 

    Childhood histiocytoses comprise two main diseases, Langerhans cell histiocytosis (LCH) and hemophagocytic lymphohistiocytosis (HLH). LCH is a rare disorder with obscure pathogenesis. Data on clonality suggested neoplastic origin, yet were not convincing. Dysregulation of cytokines and of DC...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics