Cleavage of pyrene-stabilized RNA bulge loops by trans-(n)-cyclohexane-1,2-diamine

January 2012
Chemistry Central Journal;2012, Vol. 6 Issue 1, p3
Academic Journal
The article focuses on a research paper which focuses on the cleavage of the upper stem-loop region of HIV-1 TAR RNA in a variety of buffers containing organic catalysts. It is said that chemical agents which are able to cleave HIV genome, can be used for developing anti-HIV therapy. The paper discusses the effectiveness of RNA cleaving agents like trans-()-Cyclohexane-1,2-diamine. It says that trans-()-Cyclohexane-1,2-diamine was able to cleave the RNA when the RNA was hybridized with complementary DNAs which were incorporated with a pyrene-modified C3 spacer.


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