TITLE

In vitro and in vivo characterization of a novel biocompatible implant system for the sustained delivery of Ciprofloxacin Hydrochloride

AUTHOR(S)
Pawar, Ashish Y.; Derle, Deelip V.; Gandhi, Pratik P.; Nade, V. N.; Patel, Jatin S.
PUB. DATE
September 2010
SOURCE
Journal of Pharmacy Research;Sep2010, Vol. 3 Issue 9, p2122
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the present work an attempt was made to formulate and evaluate a sustained release implant of Ciprofloxacin Hydrochloride (CFX) using biodegradable polymer Chitosan for local prevention and/or treatment of osteomyelitis. Implants (100 mg) of chitosan containing 10%, 20%, 30%, 40% and 50% of Ciprofloxacin HCl were prepared by direct compression of dry blends. The effect of different proportion of Chitosan and effect of drug loading on the drug release kinetics has been studied. An in vitro result shows that a slower percent release rate was observed with higher drug loading. In vitro study suggests that CFX-40% implant retards the drug release for more than five weeks. One CFX implant formulations were selected for implantation in the femur of rat, according to in vitro results. The implant drug loads tested were 40% of CFX. Residual polymer was explanted to determine the remaining dose of CFX. All animals remained healthy during the study. The in vivo results showed that the antibiotic concentrations achieved throughout the femur were higher for 4 weeks than the minimum inhibitory concentrations (MIC) against the most common of the pathogens that cause osteomyelitis. The CFX-40% implant was considered the best formulation as CFX was totally released within 4 weeks and therapeutic bone levels were achieved. It has also been observed that the in vitro method shows better correlation with in vivo method (r²>0.9), therefore, C4 formulation can be used to prolong Ciprofloxacin Hydrochloride HCl release for more than four weeks.
ACCESSION #
74093301

 

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