A point mutation in the DNA-binding domain of HPV-2 E2 protein increases its DNA-binding capacity and reverses its transcriptional regulatory activity on the viral early promoter

January 2012
BMC Molecular Biology;2012, Vol. 13 Issue 1, p5
Academic Journal
The article presents a study focusing on how point mutation in the DNA-binding domain of HPV-2 E2 protein increases its DNA-binding capacity. It also shows how point mutation reverses the transcriptional regulatory activity of the HPV-2 E2 protein on the viral early promoter. As stated, the findings of the study suggest that the mutation from Ala to Val at aa 338 is important for E2 DNA-binding and its transcriptional regulation.


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