Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve root

January 2012
Molecular Pain;2012, Vol. 8 Issue 1, p16
Academic Journal
The article offers information on a study that reported the antinociceptive behavior in a rats following focal demyelination produced by microinjection of lysophosphatidic acid (LPA) into the trigeminal nerve root. Sprague-Dawley rats were injected into the trigeminal nerve root to produce demyelination that decreased air-puff thresholds. Results showed that demyelination produced antinociceptive effects through neuroprotective action in animals with LPA-induced trigeminal neuropathic pain.


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