TITLE

Hepatoprotective activity of Plumeria alba and Aloe vera on CCl4 induced hepatotoxicity on male Wistar rats

AUTHOR(S)
Sudheer, M.; Babu^, B. Suresh; Divya, K.; Himavani, K. V.; Prakash, M. Siva; Srinivas, T. V. Sai
PUB. DATE
March 2011
SOURCE
Journal of Pharmacy Research;Mar2011, Vol. 4 Issue 3, p647
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Plumeria alba and Aloe vera, are described as a hepatoprotective in Ayurveda, the Indian system of medicine. However, there is no scientific basis or reports in the modern literature regarding their hepatoprotective activity. The present study was carried out to evaluate the hepatoprotective activity of both the plants and also their combination. The methanolic extract of Plumeria alba (Apocynaceae) and aqueous extract of Aloe vera (Liliaceae) were tested for their hepatoprotective activity against CCl4 induced hepatotoxicity in adult male wistar rats. The degree of protection was measured by using biochemical parameters like serum transaminases (SGOT and SGPT), alkaline phosphatase, total protein and histopathological studies. The combination of both extracts showed the significant hepatoprotective activity comparable with standard drug silymarin.
ACCESSION #
74080420

 

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