Antispasmodic and Ca++ antagonist potential of marrubiin, a labdane type diterpene from Phlomis bracteosa

Hussain, Javid; Ullah, Riaz; Khan, Arif-ullah; Mabood, Fazal; Shah, Mohammad Raza; Al-Harrasi, Ahmed; Gilani, Anwarul Hassan
January 2011
Journal of Pharmacy Research;Jan2011, Vol. 4 Issue 1, p178
Academic Journal
A tricyclic labdane type diterpene was isolated for the first time from ethyl acetate soluble part of Phlomis bracteosa. Its structure was confirmed by x-ray which was found to be marrubiin. When studied in isolated rabbit jejunum, marrubiin caused concentration-dependent relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that marrubiin exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action.


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