TITLE

Antispasmodic and Ca++ antagonist potential of marrubiin, a labdane type diterpene from Phlomis bracteosa

AUTHOR(S)
Hussain, Javid; Ullah, Riaz; Khan, Arif-ullah; Mabood, Fazal; Shah, Mohammad Raza; Al-Harrasi, Ahmed; Gilani, Anwarul Hassan
PUB. DATE
January 2011
SOURCE
Journal of Pharmacy Research;Jan2011, Vol. 4 Issue 1, p178
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A tricyclic labdane type diterpene was isolated for the first time from ethyl acetate soluble part of Phlomis bracteosa. Its structure was confirmed by x-ray which was found to be marrubiin. When studied in isolated rabbit jejunum, marrubiin caused concentration-dependent relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that marrubiin exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action.
ACCESSION #
74080373

 

Related Articles

  • Structural studies and antimicrobial properties of norcembrane diterpenoid from an Indian soft coral Sinularia inelegans Tixier-Durivault. Singh, Keisham Sarjit; Kaminsky, Werner H.; Rodrigues, Celina // Journal of Chemical Sciences;Nov2009, Vol. 121 Issue 6, p1041 

    Two metabolites featuring norcembranoid diterpene skeleton have been isolated from chloroform extract of soft coral of the genus sinularia, which was collected from the southern coast of India. The structures of the metabolites were determined by 1D, 2D NMR spectroscopic data and HRESIMS data...

  • New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla. Lei Hou; Gang Ding; Baolin Guo; Wenhua Huang; Xiaojian Zhang; Zhiyong Sun; Xiangfen Shi // Molecules;2015, Vol. 20 Issue 1, p1551 

    The new compounds 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene (1), oxyphyllenone H (2), epi-oxyphyllenone (6), (E)-labda-12,14-dien-15(16)-olide-17-oic acid (3), and two new natural products 4 and 5 were isolated from the ethyl acetate part of 95% ethanol extract of Alpinia oxyphylla,...

  • A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample. Yan Li; Dezan Ye; Zongze Shao; Chengbin Cui; Yongsheng Che // Marine Drugs;Jun2012, Vol. 10 Issue 6, p497 

    A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I-K (2-4), and the known breviones (5-8), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of...

  • Sesquiterpene lactones and new diterpenoid alkaloids from Artemisia korshinskyi. Sham'yanov, I.; Tashkhodzhaev, B.; Mukhamatkhanova, R.; Sultankhodzhaev, M.; Levkovich, M.; Abdullaev, N.; Antipin, M. // Chemistry of Natural Compounds;Sep2012, Vol. 48 Issue 4, p616 

    New diterpenoid alkaloids that were called artekorine ( 1) and 6-ketoartekorine ( 2) and had the structures 1α,14α,16β-trimethoxy-4β-N-acetylanthroyloxy-6β,8β-dihydroxy-N-ethylaconitane ( 1) and...

  • Synthesis of macrocycles with one and more ent-beyerane skeletons based on the diterpenoid isosteviol. Garifullin, B. F.; Strobykina, I. Yu.; Lodochnikova, O. A.; Musin, R. Z.; Gubaidullin, A. T.; Kataev, V. E. // Chemistry of Natural Compounds;Jul2011, Vol. 47 Issue 3, p422 

    Macrocycles with one and more ent-beyerane skeletons were prepared by the reaction of 16,19-dihydroxyent-beyerane with several dibasic carboxylic acid chlorides. The structures of the synthesized compounds, namely, the number of ent-beyerane skeletons in the macrocycle, depended on the length of...

  • A New Halimane Diterpenoid from Croton crassifolius. Zhan-Xin Zhang; Hui-Hong Li; Feng-Ming Qi; Hui-Yan Xiong; Le-Le Dong; Gai-Xia Fan; Dong-Qing Fei // Bulletin of the Korean Chemical Society;2014, Vol. 35 Issue 5, p1556 

    The article provides information on a study which examined the isolation and structural elucidation of the halimane diterpenoid crassifoliusin and the halimane diterpenoid chettaphanin from the extract of the roots of Croton (C.) crassifolius. Topics discussed include X-ray crystallographic...

  • 15,16-Epoxy-3,13(16),14-Neoclerodatrien-17,12:18,19-diolide, a new compound from Galatella punctata. Adekenov, S.; Shul'ts, E.; Gatilov, Yu.; Lomzov, A.; Atazhanova, G.; Kupriyanov, A. // Chemistry of Natural Compounds;Jan2013, Vol. 48 Issue 6, p946 

    The clerodane-type diterpenoid 5 S,8 R,9 R,10 R,12 S-15,16-epoxy-3,13(16),14-neoclerodatrien-17,12:18,19diolide was isolated during a chemical study of the aerial part of the terrestrial plant Galatella punctata. Its structure was elucidated using IR, PMR, and C NMR spectroscopy. The crystal and...

  • Comparsion of Antimicrobial Activities of Essential Oil and Solvent Extracts of Endemic Phlomis oppositiflora Boiss. & Hausskn. from Turkey. Toroğlu, Sevil; Çenet, Menderes // Pakistan Journal of Zoology;Apr2013, Vol. 45 Issue 2, p475 

    Antimicrobial activity of methanol, ethanol, ethyl acetate extracts and essential oil of Phlomis oppositiflora was investigated against eight bacteria and three fungi by disc diffusion method. The methanol, ethanol and ethyl acetate extracts of P. oppositiflora showed antibacterial activity with...

  • Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats. Pérez-Gutiérrez, Salud; Zavala-Mendoza, Daniel; Hernández-Munive, Abigail; Mendoza-Martínez, Ángel; Pérez-González, Cuauhtemoc; Sánchez-Mendoza, Ernesto // Molecules;Aug2013, Vol. 18 Issue 8, p8895 

    The antidiarrheal properties of 19-deoxyicetexone, a diterpenoid isolated from Salvia ballotiflora were evaluated on castor oil-, arachidonic acid (AA)- and prostaglandin (PGE2)-induced diarrhea in rodent models. The structure of 19-deoxyicetexone was determined by X-ray crystallography, mass...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics