TITLE

Analytical method development & validation of carvedilol by HPLC in bulk and dosage form

AUTHOR(S)
Dey, Suddhasattya; Kumar, Dhiraj; Sreenivas, S. A.; Sandeep, D.; Choudhary, Avijit
PUB. DATE
December 2010
SOURCE
Journal of Pharmacy Research;Dec2010, Vol. 3 Issue 12, p3075
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The present study indicates a simple, accurate and precise HPLC method for the estimation of Carvedilol, a ß-blocker, in bulk and pharmaceutical dosage form. The mobile phase used was 1.77g of potassium dihydrogen phosphate dissolved in distilled water and diluted to 650 ml with the same solvent; pH was adjusted to 2.0 with phosphoric acid. 350 ml of acetonitrile was added and mixed. Then it was filtered through 0.2μ membrane filter. The specification of the chromatographic system, column 4.6mm *25cm *5micron (c8), wave length 240nm, flow rate 1ml/min and the oven temperature 55°c. A linear response was observed between the concentration ranges of 806-1202μg/ml with a regression coefficient of 0.994. The method was then validated for different parameters as per the ICH (International Conference for Harmonization) guidelines. This method can be used for the determination of Carvedilol in quality control of formulation without interference of the excipients.
ACCESSION #
74080279

 

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