Oral Fluoroquinolones and the Risk of Retinal Detachment

Etminan, Mahyar; Forooghian, Farzin; Brophy, James M.; Bird, Steven T.; Maberley, David
April 2012
JAMA: Journal of the American Medical Association;4/4/2012, Vol. 307 Issue 13, p1414
Academic Journal
The article discusses a study on the association between oral fluoroquinolone use and the risk of retinal detachment. The nested case-control cohort consisted of patients who visited an ophthalmologist in the province of British Columbia between January 2000 and December 2007. It indicates an association with the use of fluoroquinolones with a significant higher risk of development a retinal detachment. It notes that only 2 doses of oral ciprofloxacin can provide adequate antipacterial concentration and suggests that damage from fluoroquinolones to collagen and connective tissue on the long bones can translate to the same type of damage to other types of connective tissue.


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