H. pylori-induced Gastric Ulcer: Pathophysiology and Herbal Remedy

Chatterjee, Ananya; Chatterjee, Sirshendu; Bandyopadhyay, Sandip K.
January 2012
International Journal of Biological & Medical Research;2012, Vol. 3 Issue 1, p1461
Academic Journal
Background: Gastric ulcer is a common, universal disease. Overall, 50% of gastric ulcers are induced by infection by Helicobacter pylori (H. pylori), a gram-negative spiral-shaped bacillus. H. pylori colonization itself is not a disease, but infection causes various clinical disorders in the upper gastrointestinal tract. The treatment for eradication of H. pylori is complicated, requiring a minimum of two antibiotics in combination with gastric acid inhibitors. Triple Therapy and Bismuth Quadruple Therapy are well-known therapeutic measures used in eradication of H. pylori and H. pylori-induced gastrointestinal disorders, but they often cause nausea, antibiotic resistance, recurrence and other side effects. As a result, there is a growing interest in non-toxic, anti-ulcer formulations from medicinal plants to treat H.pylori-induced gastric ulcers. Objectives: Review the patho-physiology of H.pylori infection and its potential herbal remedy. Methods: Summarize the published literatures collected from Pubmed/Medline, Google Scholar and other online resources. Results: Natural medicines and plant products, such as tea, resveratrol, curcumin, garlic, cinnamon, etc. can heal H. pyloriinduced gastric ulcers by scavenging the reactive oxygen and nitrogen species, boosting the host immune system, modulating host-pathogen heat shock proteins interactions. They are nontoxic in nature and hence can be used safely. Conclusion: Therefore, it is concluded that inclusion of natural antioxidants in the normal, daily diet may be the best remedial measure for continued protection from H. pylori infection.


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