TITLE

Electroencephalographic Features in Dravet Syndrome: Five-Year Follow-Up Study in 22 Patients

AUTHOR(S)
Specchio, Nicola; Balestri, Martina; Trivisano, Marina; Japaridze, Natia; Striano, Pasquale; Carotenuto, Antonio; Cappelletti, Simona; Specchio, Luigi M.; Fusco, Lucia; Vigevano, Federico
PUB. DATE
April 2012
SOURCE
Journal of Child Neurology;Apr2012, Vol. 27 Issue 4, p439
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of the study was to evaluate interictal electroencephalogram features in 22 patients with Dravet syndrome from the onset of the disease through the next 5 years. Electroencephalogram was abnormal in 5 patients (22.7%) at onset, and in 17 (77.3%) at the end of the study. Epileptiform abnormalities (focal, multifocal, or generalized) were seen in 6 patients at the onset and in 14 (27% vs 64%) at the end of the study. Photoparoxysmal response was present in 41% of patients at the end of follow-up. No statistical differences were found between mutated and nonmutated groups regarding evolution of background activity, interictal abnormalities, and presence of photoparoxysmal response. Electroencephalogram findings seemed to be age dependent, variable among different patients, and not influenced by the presence of sodium channel, voltage-gated, type I, alpha subunit (SCN1A) mutation. The lack of specific epileptiform abnormalities contributes to the difficulty of patients’ management in Dravet syndrome.
ACCESSION #
73984721

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics