March 2012
Diabetes Forecast;Mar2012, Vol. 65 Issue 3, p18
The article focuses on the study which shows that T cells killed insulin-produced beta cells in mouse pancreas tissue which provides an insight for the type 1 diabetes cause, wherein researchers suggest that keeping T cells from entering pancreas tissue will prevent the disease.


Related Articles

  • Study shows versatility of skin stem cells. Zimm, Angela // Inside Tucson Business;8/20/2001, Vol. 11 Issue 19 

    Focuses on the capability of skin stem cells to become other type of cells. Function of cells in repairing damaged nerves, brain and other tissues; Potential of the cells to cure diseases; Tests conducted on mice skin.

  • Natural killer T cells: Defining iNKT cell subpopulations. Minton, Kirsty // Nature Reviews Immunology;Mar2012, Vol. 12 Issue 3, p151 

    The article offers information on a study that sheds light on the heterogeity of invariant natural killer (iNKT) cells by defining the functional and the developmental properties of distinct subsets in mice.

  • Autoreactive Diabetogenic T-Cells in NOD Mice Can Efficiently Expand From a Greatly Reduced Precursor Pool. Serreze, David V.; Johnson, Ellis A.; Chapman, Harold D.; Graser, Robert T.; Marron, Michele P.; DiLorenzo, Teresa P.; Silveira, Pablo; Yoshimura, Yoshitaka; Nathenson, Stanley G.; Joyce, Sebastian // Diabetes;Sep2001, Vol. 50 Issue 9, p1992 

    Examines the effects of precursor pool reduction of autoreactive diabetogenic T-cells in NOD mice on the development of type 1 diabetes. Use of T-cell receptors allelic exclusion in the reduction; Prevalence of diabetogenic CD8 T-cell in the pancreatic islets of the mice.

  • Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: An alternative mechanism of allorecognition. Kreisel, Daniel; Krupnick, Alexander S.; Gelman, Andrew E.; Engels, Friederike H.; Popma, Sicco H.; Krasinskas, Alyssa M.; Balsara, Keki R.; Szeto, Wilson Y.; Turka, Laurence A.; Rosengard, Bruce R. // Nature Medicine;Mar2002, Vol. 8 Issue 3, p233 

    Despite evidence that human non-hematopoietic cells, such as vascular endothelium, can activate allogeneic T lymphocytes in vitro, the prevailing view has been that hematopoietic antigen-presenting cells are required to trigger alloimmune responses in vivo. Here we report that mouse...

  • Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40. Sotomayor, Eduardo M.; Borrello, Ivan; Tubb, Erev; Rattis, Frédérique-Marie; Bien, Harold; Lu, Zhengbin; Fein, Steve; Schoenberger, Stephen; Levitsky, Hyam I. // Nature Medicine;Jul99, Vol. 5 Issue 7, p780 

    Tumor antigen-specific T-cell tolerance limits the efficacy of therapeutic cancer vaccines. Antigenpresenting cells mediate the induction of T-cell tolerance to self-antigens. We therefore assessed the fate of tumor-specific CD4[sup +] T cells in tumor-bearing recipients after in vivo activation...

  • Label-retaining Cells in the Bulge Region are Directed to Cell Death after Plucking, Followed by Healing from the Surviving Hair Germ. Ito, Mayumi; Kizawa, Kenji; Toyoda, Masahiko; Morohashi, Masaaki // Journal of Investigative Dermatology;Dec2002, Vol. 119 Issue 6, p1310 

    Hair plucking is the most frequently used method of anagen induction within hair follicles. In this study, we found that plucking leads to the entire renewal of the follicular stem cell region of the mouse pelage follicle. Comparative histochemical analysis revealed that S100A4 protein was...

  • Allergy: SHP1 and the airways. Buckland, Jenny // Nature Reviews Immunology;Feb2003, Vol. 3 Issue 2, p94 

    Discusses a study which examined the role of SHP1 in negatively regulating T[subH]-cell development. Role in T[subH]1/T[subH]2-cell differentiation; CD4[sup+] T-cell development in the motheaten mouse; Role in the development of allergic airway inflammation.

  • Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in alphabeta... Wen, Li; Roberts, Scott J. // Nature;6/23/1994, Vol. 369 Issue 6482, p654 

    Discusses the effect of the lack of T-cell antigen receptors (TCR) on mice. Expansion of B cells; Secretion of copious amounts of antibodies of `T-dependent' isotypes.

  • Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. Yamamoto, Masamichi; Saijoh, Yukio; Perea-Gomez, Aitana; Shawlot, William; Behringer, Richard R.; Siew-Lan Ang, Richard R.; Hamada, Hiroshi; Meno, Chikara // Nature;3/25/2004, Vol. 428 Issue 6981, p387 

    Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its...

  • Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Sharif, Shayan; Arreaza, Guillermo A.; Zucker, Peter; Mi, Qing-Sheng; Sondhi, Jitin; Naidenko, Olga V.; Kronenberg, Mitchell; Koezuka, Yasuhiko; Delovitch, Terry L.; Gombert, Jean-Marc; Leite-De-Moraes, Maria; Gouarin, Christine; Zhu, Ren; Hameg, Agathe; Nakayama, Toshinori; Taniguchi, Masaru; Lepault, Françoise; Lehuen, Agnès; Bach, Jean-François // Nature Medicine;Sep2001, Vol. 7 Issue 9, p1057 

    Cites a study stating that the activation of natural killer T (NKT) cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes. Infusion of NKT cell enriched thymocyte preparations in non-obese diabetic mice; Mechanism of functioning of these cells.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics