TITLE

Biocompatibility of three different membrane oxygenators: effects on complement, neutrophil and monocyte activation

AUTHOR(S)
de Vroege, R.; Rutten, P.; Kalkman, C.; Out, T.; Jansen, P.; Eijsman, L.; de Mol, B.; Wildevuur, C.
PUB. DATE
December 1997
SOURCE
Perfusion;1997, Vol. 12 Issue 6, p369
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The inflammatory reaction of extracorporeal circuits can be assessed by measuring complement activation and the release of activation markers of leucocytes. The purpose of this study was to compare three commercially available membrane oxygenators with respect to complement (C3a), granulocyte (lactoferrin) and monocyte (interleukin-6, IL-6) activation. Thirty patients undergoing cardiac surgery were randomly assigned to undergo cardiopulmonary bypass (CPB) with one of the following oxygenators: a polypropylene hollow-fibre membrane (group 1; 2.2 m²), a polypropylene flat-sheet membrane (group 2; 3.1 m²) or a silicone envelope membrane (group 3; 3.5 m²). In all patients, a significant increase in C3a in plasma occurred during CPB with peak levels after the administration of protamine sulphate. In blood samples taken before aortic crossclamp release, at the end of CPB, and 20 min after protamine administration C3a was significantly lower in group 1 than in the other two groups. Lactoferrin increased significantly during CPB in all patients without a significant difference between the groups. IL-6 did not increase during CPB, but raised significantly after 4 h in the intensive care unit in all groups. Moreover, IL-6 was significant lower in group 1 than group 3. The data suggest that the polypropylene hollow-fibre membrane oxygenator, i.e. the oxygenator with the smallest surface area, is more biocompatible than the other types, probably because of a smaller contact surface area.
ACCESSION #
7392818

 

Related Articles

  • Orientation-Controlled Electrocatalytic Efficiency of an Adsorbed Oxygen-Tolerant Hydrogenase. Heidary, Nina; Utesch, Tillmann; Zerball, Maximilian; Horch, Marius; Millo, Diego; Fritsch, Johannes; Lenz, Oliver; von Klitzing, Regine; Hildebrandt, Peter; Fischer, Anna; Mroginski, Maria Andrea; Zebger, Ingo // PLoS ONE;11/18/2015, Vol. 10 Issue 11, p1 

    Protein immobilization on electrodes is a key concept in exploiting enzymatic processes for bioelectronic devices. For optimum performance, an in-depth understanding of the enzyme-surface interactions is required. Here, we introduce an integral approach of experimental and theoretical methods...

  • Biocomp technology being licensed.  // In Business;Jul/Aug98, Vol. 20 Issue 4, p10 

    Discusses the licensing of BioComp technology to companies. List of the companies; Information on the technology.

  • Fabrication of biocompatible dental implant screw made of pure titanium. Yoshida, Kazunari; Saiki, Yoshio; Ohkubo, Chikahiro; Kurihara, Daisuke; Osada, Tomoko; Tashima, Tadashi // Wire Journal International;Jun2011, Vol. 44 Issue 6, p88 

    The article presents a research study regarding the biocompatibility fabrication of titanium-made dental implant screw. It mentions the success of fabricating the said dental screw through drawing heading, and form rolling. It cites the workability and drawing limit of the implant screw...

  • Addressing the Inflammatory Response to Clinically Relevant Polymers by Manipulating the Host Response Using ITIM Domain-Containing Receptors. Slee, Joshua B.; Christian, Abigail J.; Levy, Robert J.; Stachelek, Stanley J. // Polymers (20734360);Oct2014, Vol. 6 Issue 10, p2526 

    Tissue contacting surfaces of medical devices initiate a host inflammatory response, characterized by adsorption of blood proteins and inflammatory cells triggering the release of cytokines, reactive oxygen species (ROS) and reactive nitrogen species (RNS), in an attempt to clear or isolate the...

  • Comparison of a Duraflo II-coated cardiopulmonary bypass circuit and a trillium-coated oxygenator during open-heart surgery. Hoel, Tom N.; Videm, Vibeke; Baksaas, Svein T; Mollnes, Tom E; Brosstad, Frank; Svennevig, Jan L // Perfusion;May2004, Vol. 19 Issue 3, p177 

    Background: Cardiopulmonary bypass (CPB) evokes a systemic inflammatory response. In attempting to improve the biocompatibility of the equipment, various methods to coat the inner surfaces of the CPB systems have been developed. The present study compares a Trillium Biopassive surface-coated...

  • Biocompatibility of Defect-Related Luminescent Nanostructured and Microstructured Hydroxyapatite. Dai, Chunyan; Duan, Jianlei; Zhang, Liang; Jia, Guang; Zhang, Cuimiao; Zhang, Jinchao // Biological Trace Element Research;Dec2014, Vol. 162 Issue 1-3, p158 

    Three defect-related luminescent hydroxyapatite (HAP) particles, S1, S2, and S3, with different morphologies (the samples S1 and S2 are nanorods with diameters of 25 nm and lengths of 30 and 100 nm, respectively; sample S3 is bur-like microspheres with diameters of 5-6 μm) were synthesized,...

  • ENDOXY - Development of a Biomimetic Oxygenator-Test-Device. Dietrich, Maren; Finocchiaro, Nicole; Olszweski, Sebastian; Arens, Jutta; Schmitz-Rode, Thomas; Sachweh, Joerg; Jockenhoevel, Stefan; Cornelissen, Christian G. // PLoS ONE;12/18/2015, Vol. 10 Issue 12, p1 

    Objective: This study focusses on the development of a biomimetic oxygenator test device. Due to limited biocompatibility, current oxygenators do not allow mid- to long-term therapy. Tissue engineering uses autologous cell sources to overcome the immunogenic barriers of biomaterials. Surface...

  • Biocompatibility of oxygen-plasma-treated polystyrene substrates. Vesel, A.; Mozetic, M.; Jaganjac, M.; Milkovic, L.; Cipak, A.; Zarkovic, N. // European Physical Journal - Applied Physics;Nov2011, Vol. 56 Issue 2, pN.PAG 

    The biocompatibility of polystyrene (PS) samples has been improved by treatment with weakly ionized highly non-equilibrium oxygen plasma. Samples were exposed to plasma for 30 s for which they have received a dose of ions of 4.5 × 1017 m−2 and a neutral oxygen atom dose of 3 ×...

  • Expression in Escherichia coli of the gene encoding ascorbate peroxidase from Brassica napus enhances salt tolerance of bacterial cells. Liu, Z.; Wan, Q.; Yue, Y.; Yang, H.; Wang, J.; Li, X.; Yang, Y. // Russian Journal of Plant Physiology;May2011, Vol. 58 Issue 3, p478 

    orbate peroxidase (APX) is an important enzyme to scavenge the reactive oxygen species (ROS), which are often caused by the salt stress. Here, APX cDNA from Brassica napus was amplified by RT-PCR and cloned into the prokaryotic expression vector pGEX-6p-1 to express BnAPX as a glutathione...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics