TITLE

Altered activation of the l-arginine nitric oxide pathway during and after cardiopulmonary bypass

AUTHOR(S)
Duke, T.; Stewart, A.
PUB. DATE
December 1997
SOURCE
Perfusion;1997, Vol. 12 Issue 6, p405
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The serum concentrations of nitrogen oxides, the stable metabolites of nitric oxide, were measured in 61 children during and after cardiopulmonary bypass (CPB) for surgery of congenital heart disease. Overall, there was a small reduction in serum nitrogen oxide concentrations during CPB, from a median of 27.5 (interquartile range 16.6--55.7) to 26.4 (15.3--40.6) mumol/l, followed by an increase in the following 24 h to 33.1 (21.3--46.7) mumol/l. The largest postoperative increases in nitrogen oxides occurred in children who developed renal impairment, or were treated with nitrovasodilators. There was no relationship between changes in serum nitrogen oxides intraoperatively and early changes in pulmonary vascular resistance, and a weak positive relationship between changes in serum nitrogen oxides and early postoperative changes in cardiac index (r² = 0.09, p = 0.04). We found no evidence for increased activation of the l-arginine nitric oxide pathway during CPB; and the reduction in nitric oxide metabolites that occurred during CPB were of doubtful significance to pulmonary or systemic haemodynamic changes in the postoperative period.
ACCESSION #
7392814

 

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