High Glucose Promotes Pancreatic Cancer Cell Proliferation via the Induction of EGF Expression and Transactivation of EGFR

Han, Liang; Ma, Qingyong; Li, Junhui; Liu, Han; Li, Wei; Ma, Guodong; Xu, Qinhong; Zhou, Shuang; Wu, Erxi
November 2011
PLoS ONE;2011, Vol. 6 Issue 11, p1
Academic Journal
Multiple lines of evidence suggest that a large portion of pancreatic cancer patients suffer from either hyperglycemia or diabetes, both of which are characterized by high blood glucose level. However, the underlying biological mechanism of this phenomenon is largely unknown. In the present study, we demonstrated that the proliferative ability of two human pancreatic cancer cell lines, BxPC-3 and Panc-1, was upregulated by high glucose in a concentration-dependent manner. Furthermore, the promoting effect of high glucose levels on EGF transcription and secretion but not its receptors in these PC cell lines was detected by using an EGF-neutralizing antibody and RT-PCR. In addition, the EGFR transactivation is induced by high glucose levels in concentration- and time-dependent manners in PC cells in the presence of the EGFneutralizing antibody. These results suggest that high glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFR. Our findings may provide new insight on the links between high glucose level and PC in terms of the molecular mechanism and reveal a novel therapeutic strategy for PC patients who simultaneously suffer from either diabetes or hyperglycemia


Related Articles

  • MicroRNA-183 inhibits apoptosis and promotes proliferation and invasion of gastric cancer cells by targeting PDCD4. Wei Gu; Tian Gao; Jie Shen; Ying Sun; Xiong Zheng; Ji Wang; Jin Ma; Xiao-Ying Hu; Jian Li; Mei-Jie Hu // International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 9, p2519 

    MicroRNA plays an important role in multiple processes of cancer development. Aberrant expression of miR-183 has been frequently reported in a variety of cancer types; however, the roles and mechanisms of miR-183 in gastric cancer are largely unknown. Here, we report that miR-183 is...

  • MicroRNA-3666 Regulates Thyroid Carcinoma Cell Proliferation via MET. Gang Wang; Chengzhong Cai; Lei Chen // Cellular Physiology & Biochemistry (Karger AG);May2016, Vol. 38 Issue 5, p1030 

    Background/Aims: Thyroid carcinoma (TC) is a highly lethal malignant cancer and its carcinogenesis remains undetermined. Dysregulation of microRNAs (miRNAs) is well known to be involved in the development of various cancers, including TC, whereas a role of miR-3666 in the pathogenesis of TC has...

  • Peptide Phage Display: Opportunities for Development of Personalized Anti-Cancer Strategies. Samoylova, T. I.; Morrison, N. E.; Globa, L. P.; Cox, N. R. // Anti-Cancer Agents in Medicinal Chemistry;2006, Vol. 6 Issue 1, p9 

    Personalized medicine is critical for cancer patients, because (1) cancer is a highly heterogeneous disease with major molecular differences in the expression and distribution of tumor cell surface markers among patients with the same type and grade of cancer, (2) cellular mutations tend to...

  • Effects of SMYD3 over-expression on cell cycle acceleration and cell proliferation in MDA-MB-231 human breast cancer cells. Ren, Tian-nian; Wang, Jing-song; He, Yun-mian; Xu, Chang-liang; Wang, Shu-zhen; Xi, Tao // Medical Oncology;Dec2011, Vol. 28, p91 

    SET and MYND domain-containing protein 3 (SMYD3) is a histone methyltransferase that plays an important role in transcriptional regulation in human carcinogenesis. It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several...

  • Therapy for Non-Clear Cell Histologies in Renal Cancer. Bitting, Rhonda L.; Madden, John; Armstrong, Andrew J. // Current Clinical Pharmacology;Aug2011, Vol. 6 Issue 3, p169 

    The advent of targeted systemic therapies has significantly improved treatment options for patients with metastatic renal cell carcinoma (RCC). Multiple agents that inhibit angiogenesis, cell growth, and proliferation via the VEGF and mTOR (TORC1) pathways have been USFDA-approved for locally...

  • The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder. Hilmy, M.; Campbell, R.; Bartlett, J. M. S.; McNicol, A.-M.; Underwood, M. A.; McMillan, D. C. // British Journal of Cancer;11/6/2006, Vol. 95 Issue 9, p1234 

    The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration, and COX-2 expression and survival was examined in patients with transitional cell carcinoma of the urinary bladder (n=103). Sixty-one patients had superficial disease and 42...

  • MGr1-Ag/37LRP promotes growth and proliferation of gastric cancer in vitro and in vivo. Liu, L; Sun, L; Wu, K; Shi, Y; Wang, Y; Zhang, N; Zhang, H // Cancer Gene Therapy;Sep2014, Vol. 21 Issue 9, p355 

    Gastric carcinoma (GC) is an aggressive cancer with a poor prognosis. We previously reported that MGr1-Ag was involved in multidrug resistance and anti-apoptosis in GC. However, the exact function of MGr1-Ag in GC proliferation is not clear. In this study, we found that MGr1-Ag was highly...

  • N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review). YAN SONG; LILI CAO // Oncology Letters;2013, Vol. 6 Issue 6, p1539 

    N-myc downstream-regulated gene 1 (NDRG1) has been reported to be a multifunctional protein associated with carcinogenesis and tumor progression. However, the cellular function of NDRG1 remains elusive in human hepatocellular carcinoma (HCC). No NDRG1 expression is observed in normal liver...

  • Restoration of WNT4 inhibits cell growth in leukemia-derived cell lines. García-Castro, Beatriz; Alvarez-Zavala, Monserrat; Riveros-Magaña, Alma R.; Ortíz-Lazareno, Pablo C.; Ratkovich-González, Sarah; Hernández-Flores, Georgina; Bravo-Cuellar, Alejandro; Jave-Suarez, Luis F.; Aguilar-Lemarroy, Adriana // BMC Cancer;2013, Vol. 13 Issue 1, p1 

    Background WNT signaling pathways are significantly altered during cancer development. Vertebrates possess two classes of WNT signaling pathways: the "canonical" WNT/ß-catenin signaling pathway, and the "non-canonical" pathways including WNT/Ca2+ and WNT/Planar cell polarity [PCP] signaling....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics