TITLE

Spectrophotometric Determination of Pregabalin Using Gibb's and MBTH reagent in Pharmaceutical Dosage Form

AUTHOR(S)
Sowjanya, K.; Thejaswini, J. C.; Gurupadayya, B. M.; Indupriya, M.
PUB. DATE
February 2011
SOURCE
Der Pharma Chemica;2011, Vol. 3 Issue 1, p112
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Two simple, extractions free spectrophotometric methods (Method 1 and 2) for the quantitative estimation of Pregabalin (PGB) in bulk drugs and pharmaceutical formulations (capsules) have been developed. Method 1 is based on the formation of a colored oxidative coupling product between 2, 6-dichloroquinone chlorimide and the drug. Colored product at its γmax 400 nm shows linearity in the concentration range of 50-350µg/ml. Second method is based on reaction of oxidative coupling of Pregabalin with 3-methyl-2-benzthiazolinone hydrazone (MBTH) to form green colored product. Colored product of γmax 668 nm shows linearity in the concentration range of 50-350 µg/ml.The relative standard deviations for first method is 0.36% and for second method is 0.35% were obtained. Linear relationships with good correlation coefficients (0.998-0.999) were found between absorbance and the corresponding concentrations of the drug. The reliability and performance of the proposed methods was validated statistically. The percentage recovery ranged from 100.42% and 99.69% respectively.
ACCESSION #
73827809

Tags: SPECTROPHOTOMETRY;  PREGABALIN;  CAPSULES (Pharmacy);  OXIDATIVE coupling;  GABAPENTIN;  PAIN management

 

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