Matching mice to malignancy: molecular subgroups and models of medulloblastoma

Lau, Jasmine; Schmidt, Christin; Markant, Shirley; Taylor, Michael; Wechsler-Reya, Robert; Weiss, William
April 2012
Child's Nervous System;Apr2012, Vol. 28 Issue 4, p521
Academic Journal
Introduction: Medulloblastoma, the largest group of embryonal brain tumors, has historically been classified into five variants based on histopathology. More recently, epigenetic and transcriptional analyses of primary tumors have subclassified medulloblastoma into four to six subgroups, most of which are incongruous with histopathological classification. Discussion: Improved stratification is required for prognosis and development of targeted treatment strategies, to maximize cure and minimize adverse effects. Several mouse models of medulloblastoma have contributed both to an improved understanding of progression and to developmental therapeutics. In this review, we summarize the classification of human medulloblastoma subtypes based on histopathology and molecular features. We describe existing genetically engineered mouse models, compare these to human disease, and discuss the utility of mouse models for developmental therapeutics. Just as accurate knowledge of the correct molecular subtype of medulloblastoma is critical to the development of targeted therapy in patients, we propose that accurate modeling of each subtype of medulloblastoma in mice will be necessary for preclinical evaluation and optimization of those targeted therapies.


Related Articles

  • Visualizing the Prostate Gland by MR Imaging in Young and Old Mice. Ravoori, Murali; Duggal, Jyoti; Gagea, Mihai; Han, Lin; Singh, Sheela; Liu, Ping; Wei, Wei; Ragan, Dustin K.; Bankson, James A.; Ma, Jingfei; Kundra, Vikas // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Purpose: Prostate imaging requires optimization in young and old mouse models. We tested which MR sequences and field strengths best depict the prostate gland in young and old mice; and, whether prostate MR signal, size, and architecture change with age. Technique: Magnetic resonance...

  • S100A8/A9 Is Not Involved in Host Defense against Murine Urinary Tract Infection. Dessing, Mark C.; Butter, Loes M.; Teske, Gwendoline J.; Claessen, Nike; van der Loos, Chris M.; Vogl, Thomas; Roth, Johannes; van der Poll, Tom; Florquin, Sandrine; Leemans, Jaklien C. // PLoS ONE;2010, Vol. 5 Issue 10, p1 

    Background: Inflammation is commonly followed by the release of endogenous proteins called danger associated molecular patterns (DAMPs) that are able to warn the host for eminent danger. S100A8/A9 subunits are DAMPs that belong to the S100 family of calcium binding proteins. S100A8/A9 complexes...

  • Mouse models for identifying genes modulating fertility parameters.  // Animal (1751-7311);Jan2009, Vol. 3 Issue 1, p55 

    Fertility can be defined as the natural capability of giving life. It is an important factor both for human medicine, where ~10% of the couples call for the services of assisted reproductive technologies, and for species of economic interest. In particular, in dairy cows, the recent years have...

  • A Mouse Model of Mosquito Allergy for Study of Antigen–Specific IgE and IgG Subclass Responses, Lymphocyte Proliferation, and IL–4 and IFN–Á Production. Chen, Yong Liang; Simons, F. Estelle R.; Peng, Zhikang // International Archives of Allergy & Immunology;Aug1998, Vol. 116 Issue 4, p269 

    To date, there are no ideal animal models for study of natural sensitization leading to IgE– and lymphocyte–mediated hypersensitivities. We established such a model in which four BALB/c mice were each sensitized by exposure to at least 16 mosquito Aedes aegypti bites, twice a week...

  • Journal of Experimental Medicine: Parkinson's protein causes disease spread in animal model.  // Biomedical Market Newsletter;4/21/2012, Vol. 21, p1 

    The article focuses on a research, in which researchers have demonstrated that brain tissue from a Parkinson's disease mouse model, as well as synthetically produced disease protein fibrils when injected into normal mice led to spreading of Parkinson's disease pathology.

  • Rod Photoreceptor Ribbon Synapses in DBA/2J Mice Show Progressive Age-Related Structural Changes. Fuchs, Michaela; Scholz, Michael; Sendelbeck, Anna; Atorf, Jenny; Schlegel, Christine; Enz, Ralf; Brandstätter, Johann Helmut; Rendon, Alvaro // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    The DBA/2J mouse is a commonly used animal model in glaucoma research. The eyes of DBA/2J mice show severe age-related changes that finally lead to the degeneration of retinal ganglion cells and the optic nerve. Recent electroretinogram studies identified functional deficits, which suggest that...

  • Chemoprevention with Enalapril and Aspirin in Men1(+/T) Knockout Mouse Model. Manoharan, Jerena; Fendrich, Volker; Di Fazio, Pietro; Bollmann, Carmen; Roth, Silvia; Joos, Barbara; Mintziras, Ioannis; Albers, Max B.; Ramaswamy, Annette; Bertolino, Philippe; Zhang, Chang X.; Slater, Emily P.; Bartsch, Detlef K.; Lopez-Lopez, Caroline L. // Neuroendocrinology;Nov2018, Vol. 107 Issue 3, p257 

    Pancreatic neuroendocrine neoplasias (pNEN) are the most common cause of death in adult patients with multiple endocrine neoplasia type 1 (MEN1). So far, only few chemopreventive strategies (e.g., with somatostatin analogues) have been evaluated for MEN1 associated pNENs. In this experimental...

  • Predicting Survival within the Lung Cancer Histopathological Hierarchy Using a Multi-Scale Genomic Model of Development. Hongye Liu; Kho, Alvin T.; Kohane, Isaac S.; Yao Sun // PLoS Medicine;Jul2006, Vol. 3 Issue 7, pe232 

    Background: The histopathologic heterogeneity of lung cancer remains a significant confounding factor in its diagnosis and prognosis—spurring numerous recent efforts to find a molecular classification of the disease that has clinical relevance. Methods and Findings: Molecular profiles of...

  • Subventricular Zone-Derived Oligodendrogenesis in Injured Neonatal White Matter in Mice Enhanced by a Nonerythropoietic Erythropoietin Derivative. Kako, Eisuke; Kaneko, Naoko; Aoyama, Mineyoshi; Hida, Hideki; Takebayashi, Hirohide; Ikenaka, Kazuhiro; Asai, Kiyofumi; Togari, Hajime; Sobue, Kazuya; Sawamoto, Kazunobu // Stem Cells (Wiley-Blackwell);Oct2012, Vol. 30 Issue 10, p2234 

    Perinatal hypoxia-ischemia (HI) frequently causes white-matter injury, leading to severe neurological deficits and mortality, and only limited therapeutic options exist. The white matter of animal models and human patients with HI-induced brain injury contains increased numbers of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics