In-body sensors to monitor cell health

Pierce, Julia
July 2002
Engineer (00137758);7/19/2002, Vol. 291 Issue 7608, p18
Reports development of dendrimer technology by researchers at the University of Michigan to produce sensors that monitor cell health. Hope of detecting pre-cancerous changes within living cells without needing blood tests; Fabrication of the sensors from dendrimers; Attachment of fluorescent tags to the dendrimeters.


Related Articles

  • Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with Caco-2 Cells. Kelly Kitchens; Amy Foraker; Rohit Kolhatkar; Peter Swaan; Hamidreza Ghandehari // Pharmaceutical Research;Nov2007, Vol. 24 Issue 11, p2138 

    Abstract Purpose  To investigate the internalization and subcellular trafficking of fluorescently labeled poly (amidoamine) (PAMAM) dendrimers in intestinal cell monolayers. Materials and methods  PAMAM dendrimers with positive or negative surface charge were...

  • VirB8: a conserved type IV secretion system assembly factor and drug target. Baron, Christian // Biochemistry & Cell Biology;Dec2006, Vol. 84 Issue 6, p890 

    Type IV secretion systems are used by many Gram-negative bacteria for the translocation of macromolecules (proteins, DNA, or DNA–protein complexes) across the cell envelope. Among them are many pathogens for which type IV secretion systems are essential virulence factors. Type IV...

  • Dumbell drugs.  // Process Engineering;Apr2005, Vol. 86 Issue 4, p10 

    This article reports that the team, led by James Baker of the Centre for Biologic Nanotechnology at the university, uses DNA as a linking tool to attach two different types of nanoparticles--one to seek out cancer cells, another for imaging or to destroy the cell. Baker's team is investigating...

  • Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Bulte, Jeff W.M.; Douglas, Trevor; Witwer, Brian; Zhang, Su-Chun; Strable, Erica; Lewis, Bobbi K.; Zywicke, Holly; Miller, Brad; van Gelderen, Peter; Moskowitz, Bruce M.; Duncan, Ian D.; Frank, Joseph A. // Nature Biotechnology;Dec2001, Vol. 19 Issue 12, p1141 

    Magnetic resonance (MR) tracking of magnetically labeled stem and progenitor cells is an emerging technology, leading to an urgent need for magnetic probes that can make cells highly magnetic during their normal expansion in culture. We have developed magnetodendrimers as a versatile class of...

  • Stop that virus. Cho, Adrian // New Scientist;08/26/2000, Vol. 167 Issue 2253, p20 

    Reports on the making of decoys on molecules to intercept viruses before they attack a cell. Research conducted by Roseita Esfand and Donald Tomalia of the University of Michigan in Ann Arbor; Replacement of linear polymers with dendrimer molecules; Dendrimer decoys which can prevent flu virus.

  • Visualizing the Needle in the Haystack: In Situ Hybridization With Fluorescent Dendrimers. Gerhart, Jacquelyn; Baytion, Michael; Perlman, Jordanna; Neely, Christine; Hearon, Bridget; Nilsen, Thor; Getts, Robert; Kadushin, James; George-Weinstein, Mindy // Biological Procedures Online;2008, Vol. 10 Issue 1, p149 

    The article focuses on a study which described the use of in situ hybridization with fluorescent dendrimers in identifying cells expressing messenger RNA (mRNA) for skeletal muscle transcription factor MyoD in a chick embryo. MyoD mRNA positive cells were present in the epiblast before the...

  • Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells. Arima, H; Arizono, M; Higashi, T; Yoshimatsu, A; Ikeda, H; Motoyama, K; Hattori, K; Takeuchi, T; Hirayama, F; Uekama, K // Cancer Gene Therapy;May2012, Vol. 19 Issue 5, p358 

    We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with α-cyclodextrin (α-CyD) having an average degree of substitution of 2.4 of α-CyD (α-CDE) provided remarkable aspects as novel carriers for DNA and small-interfering RNA. To...

  • Evaluation of Biotinylated PAMAM Dendrimer Toxicity in Models of the Blood Brain Barrier: A Biophysical and Cellular Approach. Bullen, Heather A.; Hemmer, Ruth; Cason, Chevelle; Wall, Stephen; Spaulding, Robert; Rossow, Brett; Hester, Michael; Caroway, Megan; Haik, Kristi L. // Journal of Biomaterials & Nanobiotechnology;2011 Supplement, Vol. 2, p485 

    The interaction of biotinylated G4 poly (amidoamine) (PAMAM) dendrimer conjugates and G4 PAMAM dendrimers with in vitro models of the blood brain barrier (BBB) was evaluated using Langmuir Blodgett monolayer techniques, atomic force microscopy (AFM) and lactate dehydrogenase measures of cell...

  • Stealth dendrimers for drug delivery: correlation between PEGylation, cytocompatibility, and drug payload. Hu Yang; Lopina, Stephanie; DiPersio, Linda P.; Schmidt, Steven P. // Journal of Materials Science: Materials in Medicine;May2008, Vol. 19 Issue 5, p1991 

    It is advantageous to utilize low generation polyamidoamine (PAMAM) dendrimers for drug delivery because low generations (generation 4.0 or below) have more biologically favorable properties as compared to high generations. Nevertheless, modification of low generation dendrimers with PEG to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics