TITLE

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF PERINDOPRIL ERBUMINE AND INDAPAMIDE BY RP-HPLC IN PHARMACEUTICAL DOSAGE FORMS

AUTHOR(S)
Joseph, Juddy; Philip, Blessen; Sundarapandian, M.
PUB. DATE
July 2011
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Jul2011 Supplement 4, Vol. 3, p288
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This research is concerned with the development of simple, specific, accurate and reproducible isocratic reversed phase high performance liquid chromatographic (RP-HPLC) method which is subsequently validated using ICH recommendations for the simultaneous estimation of Perindopril Erbumine (PE) and Indapamide (ID) in combined tablet dosage form. The determination was carried for a runtime of 20min at 40°C on Inertsil ODS-3V column having 250mm × 4.6mm i.d. with 5μm particle size and potassium dihydrogen phosphate buffer adjusted to pH 3.0 using ortho phosphoric acid and acetonitrile (60:40 v/v) was used as eluent at a constant flow rate of 1.0ml/min with UV detection wavelength of 215nm. The retention time of PE and ID was about 11.9 and 4.9min with correlation coefficient of 0.9992 and 0.9990 respectively. The linearity was established at 8-24μg/ml for PE and 2.5-7.5μg/ml for ID and the mean recovery for both drugs were found to be 100.3% at a load volume of 50μl.
ACCESSION #
72102246

 

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