Advani, Uma; Ansari, Anwar; Menghani, Ekta
July 2011
International Journal of Pharmacy & Pharmaceutical Sciences;Jul2011 Supplement 4, Vol. 3, p154
Academic Journal
Sesamum indicum and Allium sativum oil which has been used as an antiepileptic remedies in Chhattisgarh region was evaluated for anticonvulsiot activity against experimental seizures in mice. S. indicum (10mg/kg), Allium sativum oil (10 mg/kg) and combination of (S. indicum and A. sativum, 1:1, 10ml/kg) were significantly reduced the locomotion and rearing after 60 minutes. S. indicum oil and A. sativum oil did not produced motor impairment in the wire hanging test and catalepsy test. S. indicum (10mg/kg), Allium sativum oil (10 mg/kg) and combination of (S. indicum and A. sativum, 1:1, 10ml/kg) was significantly reduced (p<0.002) the duration of tonic hind limb extension produced by MES. Only combination of both oil was able to significantly (p<0.002) reduced the latency to death induced by the strychnine. S. indicum oil was only affective against PTZ induced seizure and both oil separately and in combination were effective against the lithium + pilocarpine induced seizure (p<0.004) It was concluded that combination of S. indicum and A. sativum oil was affective against experimental induced convulsion.


Related Articles

  • Genetic epilepsy model derived from common inbred mouse strains. Frankel, Wayne N.; Taylor, Benjamin A. // Genetics;Oct94, Vol. 138 Issue 2, p481 

    Examines the seizure displays of mice with recombinant inbred mouse strain, SWXL-4. Definition of SWXL-4; Seizure description; Localization of seizure activity by electroencephalography (EEG) and immediate gene expression; Epilepsy gene mapping by SWXL-4.

  • Exploring novel genetic factors involved in sleep/wake regulation using inter-subspecific consomic strains established from MSM/Ms and C57BL/6J mice. Tomida, Junichi // Japanese Journal of Veterinary Research;Aug2012, Vol. 60 Issue 2/3, p156 

    The article presents a study which explores the novel genetic factors involved in the regulation sleep and wakefulness using inter-subspecific consomic strains established from C57BL/6J and MSM/Ms mice. The study conducted comprehensive phenotypic analysis in B6-Chr5TMSM (5T) and B6-Chr5CMSM...

  • Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus. Riazanski, Vladimir; Deriy, Ludmila V.; Shevchenko, Pavel D.; Le, Brandy; Gomez, Erwin A.; Nelson, Deborah J. // Nature Neuroscience;Apr2011, Vol. 14 Issue 4, p487 

    The absence of the chloride channel CLC-3 in Clcn3−/− mice results in hippocampal degeneration with a distinct temporal-spatial sequence that resembles neuronal loss in temporal lobe epilepsy. We examined how the loss of CLC-3 might affect GABAergic synaptic transmission in the...

  • The 1×C3 panel of recombinant inbred mouse strains. Presence or absence of pathologic neurologic traits of one of parental strains. Boyarshinova, O. S.; Malashenko, A. M.; Bizikoeva, F. Z.; Revischin, A. V.; Lilp, I. G.; Poletaeva, I. I. // Russian Journal of Genetics;Feb2009, Vol. 45 Issue 2, p247 

    Mice from the earlier developed recombinant inbred strains (RIS), which were derived by crossing 101/HY mice (carrying the mut-1 allele determining increased susceptibility to the mutagenic action of alkylating compounds) with C3H/Sn mice (lacking this trait), were tested for the presence of two...

  • Taming TLR4 may ease seizures. Kleen, Jonathan K.; Holmes, Gregory L. // Nature Medicine;Apr2010, Vol. 16 Issue 4, p369 

    The article reports on a study which found that toll-like receptors (TLR) of an inflammatory pathway are active in both acute seizures and chronic epilepsy. Researchers examine the pattern of high-mobility group box-1(HMGB1) and TLR4 staining in the hippocampi of mice that leads to chronic...

  • Metabotropic Glutamate Receptor 7 Modulates the Rewarding Effects of Cocaine in Rats: Involvement of a Ventral Pallidal GABAergic Mechanism. Xia Li; Jie Li; Xiao-Qing Peng; Spiller, Krista; Gardner, Eliot L.; Zheng-Xiong Xi // Neuropsychopharmacology;Jun2009, Vol. 34 Issue 7, p1783 

    The metabotropic glutamate receptor 7 (mGluR7) has received much attention as a potential target for the treatment of epilepsy, major depression, and anxiety. In this study, we investigated the possible involvement of mGluR7 in cocaine reward in animal models of drug addiction. Pretreatment with...

  • Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Marsh, Eric; Fulp, Carl; Gomez, Ernest; Nasrallah, Ilya; Minarcik, Jeremy; Sudi, Jyotsna; Christian, Susan L.; Mancini, Grazia; Labosky, Patricia; Dobyns, William; Brooks-Kayal, Amy; Golden, Jeffrey A. // Brain: A Journal of Neurology;Jun2009, Vol. 132 Issue 6, p1563 

    Mutations in the X-linked aristaless-related homeobox gene (ARX) have been linked to structural brain anomalies as well as multiple neurocognitive deficits. The generation of Arx-deficient mice revealed several morphological anomalies, resembling those observed in patients and an interneuron...

  • How Ready Can a Synaptic Vesicle Be? SV2 May Have the Answer. Mathews, Gregory C. // Epilepsy Currents;Nov/Dec2009, Vol. 9 Issue 6, p172 

    Synaptic vesicle protein 2 (SV2), one of the first synaptic vesicle proteins identified, is characterized by multiple transmembrane regions that exhibit homology to sugar transporters, and by a highly glycosylated intravesicular sequence. Deletion of SV2 causes postnatal lethality in mice,...

  • Astrocyte Networks and Epilepsy: When Stars Collide. Wong, Michael // Epilepsy Currents;Jul/Aug2009, Vol. 9 Issue 4, p113 

    Gliosis is a pathological hallmark of posttraumatic epileptic foci, but little is known about these reactive astrocytes beyond their high glial fibrillary acidic protein (GFAP) expression. Using diolistic labeling, we show that cortical astrocytes lost their nonoverlapping domain organization in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics