Advani, Uma; Ansari, Anwar; Menghani, Ekta
July 2011
International Journal of Pharmacy & Pharmaceutical Sciences;Jul2011 Supplement 4, Vol. 3, p154
Academic Journal
Sesamum indicum and Allium sativum oil which has been used as an antiepileptic remedies in Chhattisgarh region was evaluated for anticonvulsiot activity against experimental seizures in mice. S. indicum (10mg/kg), Allium sativum oil (10 mg/kg) and combination of (S. indicum and A. sativum, 1:1, 10ml/kg) were significantly reduced the locomotion and rearing after 60 minutes. S. indicum oil and A. sativum oil did not produced motor impairment in the wire hanging test and catalepsy test. S. indicum (10mg/kg), Allium sativum oil (10 mg/kg) and combination of (S. indicum and A. sativum, 1:1, 10ml/kg) was significantly reduced (p<0.002) the duration of tonic hind limb extension produced by MES. Only combination of both oil was able to significantly (p<0.002) reduced the latency to death induced by the strychnine. S. indicum oil was only affective against PTZ induced seizure and both oil separately and in combination were effective against the lithium + pilocarpine induced seizure (p<0.004) It was concluded that combination of S. indicum and A. sativum oil was affective against experimental induced convulsion.


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