Advani, Uma; Ansari, Anwar; Menghani, Ekta
July 2011
International Journal of Pharmacy & Pharmaceutical Sciences;Jul2011 Supplement 4, Vol. 3, p154
Academic Journal
Sesamum indicum and Allium sativum oil which has been used as an antiepileptic remedies in Chhattisgarh region was evaluated for anticonvulsiot activity against experimental seizures in mice. S. indicum (10mg/kg), Allium sativum oil (10 mg/kg) and combination of (S. indicum and A. sativum, 1:1, 10ml/kg) were significantly reduced the locomotion and rearing after 60 minutes. S. indicum oil and A. sativum oil did not produced motor impairment in the wire hanging test and catalepsy test. S. indicum (10mg/kg), Allium sativum oil (10 mg/kg) and combination of (S. indicum and A. sativum, 1:1, 10ml/kg) was significantly reduced (p<0.002) the duration of tonic hind limb extension produced by MES. Only combination of both oil was able to significantly (p<0.002) reduced the latency to death induced by the strychnine. S. indicum oil was only affective against PTZ induced seizure and both oil separately and in combination were effective against the lithium + pilocarpine induced seizure (p<0.004) It was concluded that combination of S. indicum and A. sativum oil was affective against experimental induced convulsion.


Related Articles

  • Genetic epilepsy model derived from common inbred mouse strains. Frankel, Wayne N.; Taylor, Benjamin A. // Genetics;Oct94, Vol. 138 Issue 2, p481 

    Examines the seizure displays of mice with recombinant inbred mouse strain, SWXL-4. Definition of SWXL-4; Seizure description; Localization of seizure activity by electroencephalography (EEG) and immediate gene expression; Epilepsy gene mapping by SWXL-4.

  • Exploring novel genetic factors involved in sleep/wake regulation using inter-subspecific consomic strains established from MSM/Ms and C57BL/6J mice. Tomida, Junichi // Japanese Journal of Veterinary Research;Aug2012, Vol. 60 Issue 2/3, p156 

    The article presents a study which explores the novel genetic factors involved in the regulation sleep and wakefulness using inter-subspecific consomic strains established from C57BL/6J and MSM/Ms mice. The study conducted comprehensive phenotypic analysis in B6-Chr5TMSM (5T) and B6-Chr5CMSM...

  • Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus. Riazanski, Vladimir; Deriy, Ludmila V.; Shevchenko, Pavel D.; Le, Brandy; Gomez, Erwin A.; Nelson, Deborah J. // Nature Neuroscience;Apr2011, Vol. 14 Issue 4, p487 

    The absence of the chloride channel CLC-3 in Clcn3−/− mice results in hippocampal degeneration with a distinct temporal-spatial sequence that resembles neuronal loss in temporal lobe epilepsy. We examined how the loss of CLC-3 might affect GABAergic synaptic transmission in the...

  • The 1×C3 panel of recombinant inbred mouse strains. Presence or absence of pathologic neurologic traits of one of parental strains. Boyarshinova, O. S.; Malashenko, A. M.; Bizikoeva, F. Z.; Revischin, A. V.; Lilp, I. G.; Poletaeva, I. I. // Russian Journal of Genetics;Feb2009, Vol. 45 Issue 2, p247 

    Mice from the earlier developed recombinant inbred strains (RIS), which were derived by crossing 101/HY mice (carrying the mut-1 allele determining increased susceptibility to the mutagenic action of alkylating compounds) with C3H/Sn mice (lacking this trait), were tested for the presence of two...

  • Taming TLR4 may ease seizures. Kleen, Jonathan K.; Holmes, Gregory L. // Nature Medicine;Apr2010, Vol. 16 Issue 4, p369 

    The article reports on a study which found that toll-like receptors (TLR) of an inflammatory pathway are active in both acute seizures and chronic epilepsy. Researchers examine the pattern of high-mobility group box-1(HMGB1) and TLR4 staining in the hippocampi of mice that leads to chronic...

  • How Ready Can a Synaptic Vesicle Be? SV2 May Have the Answer. Mathews, Gregory C. // Epilepsy Currents;Nov/Dec2009, Vol. 9 Issue 6, p172 

    Synaptic vesicle protein 2 (SV2), one of the first synaptic vesicle proteins identified, is characterized by multiple transmembrane regions that exhibit homology to sugar transporters, and by a highly glycosylated intravesicular sequence. Deletion of SV2 causes postnatal lethality in mice,...

  • Astrocyte Networks and Epilepsy: When Stars Collide. Wong, Michael // Epilepsy Currents;Jul/Aug2009, Vol. 9 Issue 4, p113 

    Gliosis is a pathological hallmark of posttraumatic epileptic foci, but little is known about these reactive astrocytes beyond their high glial fibrillary acidic protein (GFAP) expression. Using diolistic labeling, we show that cortical astrocytes lost their nonoverlapping domain organization in...

  • Is Epilepsy a Disease of Synaptic Transmission? Kapur, Jaideep // Epilepsy Currents;Sep/Oct2008, Vol. 8 Issue 5, p139 

    Glasscock E, Qian J, Yoo JW, Noebels JL. Nat Neurosci 2007;10(12):1554–1558. Inherited errors in ion channel genes comprise the largest subset of monogenic causes of idiopathic epilepsy, and pathogenic variants contribute to genetic risk in the complex inheritance of this common disorder....

  • Multi-electrode array study of neuronal cultures expressing nicotinic β2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy. Gullo, Francesca; Manfredi, Irene; Lecchi, Marzia; Casari, Giorgio; Wanke, Enzo; Becchetti, Andrea // Frontiers in Neural Circuits;Jul2014, Vol. 8, p1 

    Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a partial sleep-related epilepsy which can be caused by mutant neuronal nicotinic acetylcholine receptors (nAChR). We applied multi-electrode array (MEA) recording methods to study the spontaneous firing activity of neocortical...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics