TITLE

Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats

AUTHOR(S)
Tang, Yu; Liao, Yonghui; Kawaguchi-Sakita, Nobuko; Raut, Vikram; Fakhrejahani, Elham; Qian, Niansong; Toi, Masakazu
PUB. DATE
July 2011
SOURCE
Journal of Hepato -- Biliary -- Pancreatic Sciences;Jul2011, Vol. 18 Issue 4, p551
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background/purpose: Sinisan, a traditional Chinese medicine, is effective for the treatment of gastrointestinal disorders. In this study, we investigated the potential protective role of Sinisan against chronic pancreatitis (CP) in rats. Methods: CP was induced in rats by intrapancreatic injection of trinitrobenzene sulfonic acid (TNBS). Rats were randomly divided into a sham group, a TNBS-induced CP group and a Sinisan-treated group. Serum amylase and histological score were used to evaluate the severity of disease. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), interleukin-10 (IL-10) and α-smooth muscle actin (α-SMA) were also measured in the three groups. Mechanical allodynia was measured with von Frey filaments. In addition, the protein levels of nerve growth factor (NGF) were measured in pancreatic tissues. Results: Administration of Sinisan significantly decreased the severity of CP. In the Sinisan-treated group, serum amylase, TNF-α, IL-1β, COX-2 and α-SMA levels were lower and the level of IL-10 was upregulated compared with the TNBS-induced CP group. Furthermore, treatment with Sinisan significantly, though not completely, attenuated the allodynia. Simultaneously NGF expression was also significantly downregulated in the Sinisan-treated group compared with the TNBS-induced CP group. Conclusions: Sinisan could be an effective treatment modality for CP via its anti-inflammatory, anti-fibrotic and analgesic properties. It may be a promising drug candidate for the treatment of patients with CP.
ACCESSION #
71777186

 

Related Articles

  • Targeting oxidative stress attenuates trinitrobenzene sulphonic acid induced inflammatory bowel disease like symptoms in rats: Role of quercetin. Dodda, Dilip; Chhajed, Ruchi; Mishra, Jitendriya; Padhy, Monalisa // Indian Journal of Pharmacology;May/Jun2014, Vol. 46 Issue 3, p286 

    Objective: This study was aimed to investigate the beneficial effects of quercetin (QCT) against trinitrobenzene sulfonic acid (TNBS) induced clinical, morphological, and biochemical alterations in rats. Materials and Methods: Colitis in rats was induced by administration of TNBS (25 mg...

  • IN VITRO INVESTIGATION OF THE ANTIHYPERTENSIVE EFFECT OF THE MOSS RHODOBRYUM ONTARIENSE (KINDB.) (KINDB.). Pejin, Boris; Kien-Thai, Yong; Bogdanovic-Pristov, Jelena; Pejin, Ivana; Spasojevic, Ivan // Digest Journal of Nanomaterials & Biostructures (DJNB);Jan-Mar2012, Vol. 7 Issue 1, p353 

    The ability to modulate erythrocyte membrane fluidity, the capacity to release nitric oxide and the ABTS [2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)] cation scavenging activity including the total phenolic content screening of the moss Rhodobryum ontariense tea, a traditional Chinese...

  • Continuous Flushing of the Bladder in Rodents Reduces Artifacts and Improves Quantification in Molecular Imaging. Deleye, Steven; Heylen, Marthe; Deiteren, Annemie; De Man, Joris; Stroobants, Sigrid; De Winter, Benedicte; Staelens, Steven // Molecular Imaging;2014, Vol. 13 Issue 5, p1 

    In this study, we evaluated the partial volume effect (PVE) of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) tracer accumulation in the bladder on the positron emission tomographic (PET) image quantification in mice and rats suffering from inflammatory bowel disease. To improve the accuracy, we...

  • The effect of betulinic acid on TNBS-induced experimental colitis. Şener, Tarık Emre; Kardaş, Rıza Can; Şehirli, Ahmet Özer; Ekşioğlu-Demiral, Emel; Yüksel, Meral; Çetinel, Şule; Yeğen, Berrak C.; Şener, Göksel // Marmara Pharmaceutical Journal;Jan2013, Vol. 17 Issue 1, p52 

    In this study we have investigated the possible protective effect of betulinic acid (BA) on colonic inflammation in rats. Colitis was induced in Sprague-Dawley rats of both sexes by intracolonic administration of 1 ml trinitrobenzene sulphonic acid (TNBS). Colitisinduced rats received...

  • Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid. Aihua Qian; Dandan Song; Yong Li; Xinqiu Liu; Dong Tang; Weiyan Yao; Yaozong Yuan // Molecular Pain;2013, Vol. 9 Issue 1, p1 

    Background: Visceral pain is common symptom involved in many gastrointestinal disorders such as inflammatory bowel disease. The underlying molecular mechanisms remain elusive. We investigated the molecular mechanisms and the role for voltage gated calcium channel (VGCC) in the pathogenesis in a...

  • Protective effects of Aegle marmelos fruit pulp on 2,4,6-trinitrobenzene sulfonic acid-induced experimental colitis. Ghatule, Rohit R.; Gautam, Manish K.; Goel, Shalini; Singh, Amit; Joshi, Vinod K.; Goel, Raj K. // Pharmacognosy Magazine;Jan-Mar2014 Supplement, Vol. 10 Issue 37S, pS147 

    Background: Aegle marmelos (AM) fruit has been advocated in indigenous system of medicine for the treatment of various gastrointestinal disorders, fever, asthma, inflammations, febrile delirium, acute bronchitis, snakebite, epilepsy, leprosy, myalgia, smallpox, leucoderma, mental illnesses,...

  • A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents. Randhawa, Puneet Kaur; Singh, Kavinder; Singh, Nirmal; Jaggi, Amteshwar Singh // Korean Journal of Physiology & Pharmacology;2014, Vol. 18 Issue 4, p279 

    Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological factors involved in the perpetuation of IBD remain uncertain,...

  • Azadirachta indica Attenuates Colonic Mucosal Damage in Experimental Colitis Induced by Trinitrobenzene Sulfonic Acid. GAUTAM, M. K.; GOEL, SHALINI; GHATULE, R. R.; SINGH, A.; JOSHI, V. K.; GOEL, R. K. // Indian Journal of Pharmaceutical Sciences;Sep/Oct2013, Vol. 75 Issue 5, p602 

    Azadirachta indica leaves indicated the presence of active principles with proven antioxidants, antiinflammatory, immunomodulatory, free radical scavenging and healing properties. In the present study we evaluated the healing effects of 50% ethanol extract of dried leaves of Azadirachta indica...

  • Allicin Alleviates Inflammation of Trinitrobenzenesulfonic Acid-Induced Rats and Suppresses P38 and JNK Pathways in Caco-2 Cells. Li, Chen; Lun, Weijian; Zhao, Xinmei; Lei, Shan; Guo, Yandong; Ma, Jiayi; Zhi, Fachao // Mediators of Inflammation;2/2/2015, Vol. 2015, p1 

    Background. Allicin has anti-inflammatory, antioxidative and proapoptotic properties. Aims. To evaluate the effects and investigate the mechanism of allicin on trinitrobenzenesulfonic acid-induced colitis, specifically with mesalazine or sulfasalazine. Methods. 80 rats were divided equally into...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics