TITLE

Formulation and Evaluation of Gastro retentive Floating Drug Delivery System of Ofloxacin

AUTHOR(S)
Srikanth, M. V.; Rao, N. Sreenivasa; Sunil, S. A.; Sharma, G. S.; Uhumwangho, M. U.; Murthy, K. V. Ramana
PUB. DATE
March 2011
SOURCE
Drug Invention Today;Mar2011, Vol. 3 Issue 3, p7
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The objective of this present study is to formulate and evaluate the gastroretentive floating drug delivery system (GRFDDS) of ofloxacin prepared by using synthetic and natural polymers (polyethylene oxide and gum karaya). Formulations were prepared by wet granulation technique and sodium bicarbonate (10% w/w) was incorporated as gas generating agent. Tablets were evaluated for hardness, in vitro buoyancy, drug content and in vitro drug release studies. Release data obtained was subjected to analysis using different mathematical models namely - zero order flux, first order, erosion plot, Higuchi and Korsmeyer peppas equations. All formulated tablets irrespective of polymer used had hardness and friability values >5.0kg/cm2 and <0.68%. The in vitro lag time and total buoyancy time for all the formulations were between 45 to 183secs and 5 to 16 hrs respectively. As the concentration of the polymers in the formulations increased the drug release decreased. Formulations made with gum karaya exhibited first order kinetics, non- fickian diffusion and the formulations like OGK3 and OGK4 followed first order and erosion mechanism. Whereas polyethylene oxide based formulations OP2,OP4 and OP5 exhibited zero order, non fickian diffusion and remaining formulations followed first order, erosion mechanism. GRFDDs of ofloxacin using synthetic (polyethylene oxide) and natural polymer (gum karaya) with drug to polymer ratio 1:0.5 and 1: 0.625 respectively are final optimized formulations. These were further characterized by Fourier transform infrared spectroscopy (FTIR) which indicated that there was no interaction between drug and polymers.
ACCESSION #
71738618

 

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