TITLE

Formaldehyde suppresses neuronal apoptosis via inhibition of outward K+ currents in rat hippocampus

AUTHOR(S)
Liu, Pei; Guo, Jianli; Qi, Zhi
PUB. DATE
November 2011
SOURCE
Canadian Journal of Physiology & Pharmacology;Nov2011, Vol. 89 Issue 11, p837
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Formaldehyde (FA) is widely present in the environment, and is also a mammalian metabolite. However, its biological role has not been well understood. Here, we show that FA plays an anti-apoptotic role in cultured hippocampal neurons: FA suppressed staurosporine-induced neuronal apoptosis and inhibited the activity of apoptosis-associated caspase-3/7 proteases in a concentration-dependent manner. Moreover, FA suppressed outward K+ currents and attenuated the enhanced IK currents that are associated with neuronal apoptosis. As an increase in outward K+ currents is critical for cell apoptosis, our results suggest that FA exerts its anti-apoptotic effects on neuronal cells, probably through its inhibitory effect on the outward K+ currents.
ACCESSION #
71529941

 

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