TITLE

Characterization of Nipah Virus from Outbreaks in Bangladesh, 2008-2010

AUTHOR(S)
Lo, Michael K.; Lowe, Luis; Hummel, Kimberly B.; Sazzad, Hossain M. S.; Gurley, Emily S.; Hossain, M. Jahangir; Luby, Stephen P.; Miller, David M.; Comer, James A.; Rollin, Pierre E.; Bellini, William J.; Rota, Paul A.
PUB. DATE
February 2012
SOURCE
Emerging Infectious Diseases;Feb2012, Vol. 18 Issue 2, p248
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.
ACCESSION #
71525712

 

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