TITLE

Rib fracture as a predictor of future fractures in young and older postmenopausal women: National Osteoporosis Risk Assessment (NORA)

AUTHOR(S)
Sajjan, S.; Barrett-Connor, E.; McHorney, C.; Miller, P.; Sen, S.; Siris, E.
PUB. DATE
March 2012
SOURCE
Osteoporosis International;Mar2012, Vol. 23 Issue 3, p821
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Summary: A rib fracture history after age 45 was associated with a 5.4-fold increase in new rib fracture risk and a 2.4-fold increase in risk of any new clinical fracture in 155,031 postmenopausal women. A rib fracture history suggests osteoporosis and should be considered when evaluating patients for interventions to prevent fractures. Introduction: Until recently, little attention was paid to rib fracture as an osteoporosis marker. Emerging evidence suggests rib fracture may be an osteoporotic fracture in men and women. We report the 5-year independent association between baseline rib fracture histories and self-reported future fractures by age (decade) in the NORA cohort (155,031 postmenopausal women, 50-99 years). Methods: Participants reported fracture history and responded to follow-up surveys at years 1, 3, or 6. Women with a baseline rib fracture history without other fractures were compared with women with no fracture. Results: At baseline, 4,758 (3.07%) women reported a rib fracture history without other fractures; 6,300 women reported 6,830 new clinical fractures, including wrist (2,271), rib (1,891), spine (1,136), hip (941), and forearm (591). Adjusted relative risk (ARR) values (95% confidence interval [CI]) for future fractures in women with rib fracture history versus women with no fracture history were 5.4 (4.8-6.1) at the rib, 2.1 (1.7-2.6) at the spine, and 1.4 (1.1-1.7) at the wrist, and not significant for forearm or hip fractures. Future fracture risk was at least doubled in women with a rib fracture history in all ages: ARR (95% CI) 3.4 (2.8-4.0) for ages 50-59, 2.5 (2.1-3.0) for ages 60-69, 2.0 (1.7-2.3) for ages 70-79, and 2.0 (1.6-2.6) for ages >80. Conclusions: Rib fracture, the second most common clinical fracture in women (after wrist fracture), predicted future fractures of the rib, wrist, and spine at all ages. Women presenting with rib fractures should be evaluated for appropriate management to prevent future fractures.
ACCESSION #
71509541

 

Related Articles

  • The effects of adiponectin and leptin on changes in bone mineral density. Barbour, K.; Zmuda, J.; Boudreau, R.; Strotmeyer, E.; Horwitz, M.; Evans, R.; Kanaya, A.; Harris, T.; Cauley, J. // Osteoporosis International;Jun2012, Vol. 23 Issue 6, p1699 

    Summary: We tested the hypothesis that low leptin and high adiponectin levels are associated with higher rates of bone mineral density (BMD) loss among 3,075 men and women, aged 70-79, from the Health Aging and Body Composition Study. Results suggest that adiponectin, but not leptin, is a risk...

  • Impaired trabecular and cortical microarchitecture in daughters of women with osteoporotic fracture: the MODAM study. Nagy, H.; Sornay-Rendu, E.; Boutroy, S.; Vilayphiou, N.; Szulc, P.; Chapurlat, R. // Osteoporosis International;Jun2013, Vol. 24 Issue 6, p1881 

    Summary: We investigated the familial resemblance of bone microarchitecture parameters between postmenopausal mothers with fragility fracture and their premenopausal daughters using high-resolution peripheral quantitative computed tomography (HR-pQCT). We found that daughters of women with...

  • Spine-hip discordance and fracture risk assessment: a physician-friendly FRAX enhancement. Leslie, W. D.; Lix, L. M.; Johansson, H.; Oden, A.; McCloskey, E.; Kanis, J. A. // Osteoporosis International;Mar2011, Vol. 22 Issue 3, p839 

    Summary: The FRAX® tool estimates a 10-year probability of fracture based upon multiple clinical risk factors and an optional bone mineral density (BMD) measurement obtained from the femoral neck. We describe a simple procedure for using lumbar spine BMD to enhance fracture risk assessment...

  • Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort. Abellan Van Kan, Gabor; Cesari, Matteo; Gillette-Guyonnet, Sophie; Dupuy, Charlotte; Nourhashémi, Fati; Schott, Anne-Marie; Beauchet, Olivier; Annweiler, Cédric; Vellas, Bruno; Rolland, Yves // Age & Ageing;Mar2013, Vol. 42 Issue 2, p196 

    Background: common pathophysiological pathways are shared between age-related body composition changes and cognitive impairment.Objective: evaluate whether current operative sarcopenia definitions are associated with cognition in community-dwelling older women.Design: cross-sectional...

  • Prevalence of osteoporosis among cancer patients in Germany. Reuss-Borst, M.; Hartmann, U.; Scheede, C.; Weiß, J. // Osteoporosis International;Apr2012, Vol. 23 Issue 4, p1437 

    Summary: In this prospective study, we measured bone mineral density (BMD) in 1,041 cancer patients undergoing an oncological rehabilitation program in an inpatient rehabilitation clinic. There was an osteoporosis prevalence of approximately 16%, independent of sex, which is considerably higher...

  • The impact of body mass index in old age on cause-specific mortality. Hollander, Ellen; Zutphen, M.; Bogers, R.; Bemelmans, W.; Groot, L. // Journal of Nutrition, Health & Aging;Jan2012, Vol. 16 Issue 1, p100 

    Objectives: To assess the association between Body Mass Index (BMI) and cause-specific mortality in older adults and to assess which BMI was associated with lowest mortality. Design: Prospective study. Setting: European towns. Participants: 1,980 older adults, aged 70-75 years from the SENECA...

  • Risk factors for peripheral fractures vary by age in older men-the prospective MINOS study. Blaizot, S.; Delmas, P. D.; Marchand, F.; Chapurlat, R.; Szulc, P. // Osteoporosis International;Jun2011, Vol. 22 Issue 6, p1755 

    Summary: Identification of older men at high risk of peripheral fracture can be improved by assessing prevalent fractures (men aged ≤65), history of falls (men aged >65), bone width, and aortic calcifications. Introduction: Low bone mineral density (BMD) identifies 20% of men who sustain...

  • Noninvasive assessment of bone health in Indian patients with chronic kidney disease. Jabbar, Z.; Aggarwal, P. K.; Chandel, N.; Khandelwal, N.; Kohli, H. S.; Sakhuja, V.; Jha, V. // Indian Journal of Nephrology;May/Jun2013, Vol. 23 Issue 3, p166 

    Abnormalities in mineral and bone disease are common in chronic kidney disease (CKD). Evaluation of bone health requires measurement of parameters of bone turnover, mineralization, and volume. There are no data on bone health in CKD patients from India. In this cross-sectional study, we...

  • Testing and treatment for osteoporosis following hip fracture in an integrated U.S. healthcare delivery system. Shibli-Rahhal, A.; Vaughan-Sarrazin, M.; Richardson, K.; Cram, P. // Osteoporosis International;Dec2011, Vol. 22 Issue 12, p2973 

    Summary: Older veterans with acute hip fracture do not receive adequate evaluation and treatment for osteoporosis, irrespective of their age and underlying health status. Introduction: Hip fractures are a serious complication of osteoporosis, leading to high mortality and morbidity. Prior...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics