Papiță¹, Anamaria; Albu², Adriana; Fodor², Daniela; Itu¹, Corina; Cârstina³, D.
June 2011
Therapeutics, Pharmacology & Clinical Toxicology;2011, Vol. 15 Issue 2, p111
Academic Journal
Background: Cardiovascular disease is an increasing cause of morbidity and mortality in HIV-infected patients. The increased cardiovascular risk in HIV infected patients is linked to traditional risk factors but also to HIV infection itself which can damage the arterial wall. The antiretroviral treatment (ART) is implicated in metabolic disturbances which can also affect the arterial wall. The aim of our study was to identify the effects of HIV and ART on the aortic artery and the cardiovascular risk by the evaluation of arterial stiffness parameters. Material and methods: A cross-sectional case-control study of 59 HIV-infected patients (55 exposed to ART, 5 ART-naïve) and 40 controls matched by age and sex was performed. Aortic stiffness parameters and brachial parameters were measured using a device called Arteriograf TensioMed attached to a laptop with a TensioMed special software which provided automatic calculations of these markers. Results: HIV-infected patients had a greater aortic pulse wave velocity than the control group (p=0.02) and an increased heart rate (p=0.02). HIV infection and ARV treatment are additional risk factors for rapid onset and progression of atherosclerosis. Conclusions: HIV infection and ARV treatment are associated with increased arterial stiffness and increased heart rate. These vascular alterations are possible causes of the increased cardiovascular risk observed in HIV infected patients.


Related Articles

  • Prevalence of Dyslipidemia and Metabolic Abnormalities in HIV-Infected Patients. Ramezani, Amitis; Mohraz, Minoo; Yadegarinia, Davood; Banifazl, Mohammad; Gachkar, Latif; Jam, Sara; Aghakhani, Arezoo; Eslamifar, Ali; Yaghmaie, Farhad; Nemati, Kambiz; Velayati, Ali Akbar // Acta Medica Iranica;2009, Vol. 47 Issue 2, p83 

    Dyslipidemia has become a common problem in human immunodeficiency virus (HIV) disease, especially in patients on combination antiretroviral therapy. We investigated the prevalence of and factors associated with dyslipidemia in HIV-infected patients in Iran. In this cross-sectional study, 190...

  • A cross-sectional, population-based study measuring comorbidity among people living with HIV in Ontario. Kendall, Claire E.; Wong, Jenna; Taljaard, Monica; Glazier, Richard H.; Hogg, William; Younger, Jaime; Manuel, Douglas G. // BMC Public Health;2014, Vol. 14 Issue 1, p1 

    Background As people diagnosed with HIV and receiving combination antiretroviral therapy are now living longer, they are likely to acquire chronic conditions related to normal ageing and the effects of HIV and its treatment. Comordidities for people with HIV have not previously been described...

  • Antiretroviral therapy, CD4, viral load, and disease stage in HIV patients in Saudi Arabia: a 2001-2013 cross-sectional study. Memish, Ziad A.; Al-Tawfiq, Jaffar A.; Filemban, Sanaa M.; Qutb, Sayed; Fodail, Abdullah; Ali, Batol; Darweeish, May // Journal of Infection in Developing Countries;Jul2015, Vol. 9 Issue 7, p765 

    Introduction: The incidence of HIV/AIDS is increasing worldwide and in the Middle East. In this study, we analyzed the use of antiretroviral therapy (ART), the patterns of CD4 and viral load (VL), and stage of presentation. Methodology: Laboratory variables, ART use, and CD4 count were obtained...

  • Alcohol Use and Subsequent Sex among HIV-Infected Patients in an Ethnic Minority Area of Yunnan Province, China. Luo, Xiaofeng; Duan, Song; Duan, Qixiang; Pu, Yongcheng; Yang, Yuecheng; Ding, Yingying; Gao, Meiyang; He, Na // PLoS ONE;Apr2013, Vol. 8 Issue 4, p1 

    Objective: To examine alcohol use and subsequent HIV risky behaviors among a sample of predominately ethnic minority people living with HIV/AIDS (PLWHA) in a rural community in Yunnan Province, China. Method: A cross-sectional study with a face-to-face questionnaire interview was conducted...

  • Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study. Shiferaw, Melashu Balew; Tulu, Ketema Tafess; Zegeye, Amtatachew Moges; Wubante, Amarech Asratie // AIDS Research & Treatment;7/14/2016, p1 

    Liver disease has emerged as the most common non-AIDS-related cause of death in HIV patients. However, there is limited data regarding this condition including our setting in Ethiopia. Hence, liver enzyme abnormalities among highly active antiretroviral therapy (HAART) experienced and HAART...

  • THERAPEUTIC STRATEGIES IN HIV INFECTED PATIENTS IN TREATMENT FAILURE. Stoian, Andreea Cristina; Dumitrescu, Florentina; Cupsa, A.; Iocu, Cristina; Niculescu, Irina; Giubelan, L.; Marinescu, Liliana // Therapeutics, Pharmacology & Clinical Toxicology;2011, Vol. 15 Issue 2, p117 

    Objectives: Analisys of clinical course after changing antiretroviral therapy (ART) in HIV infected patients (Px) with treatment failure (TF). Methods: A retrospective study in Craiova Regional Center for Monitoring and Evaluation of HIV/AIDS from 01/01/2009 to 12/31/2009, on two groups of Px in...

  • MANAGEMENT OF A TREATMENT EXPERIENCED HIV PATIENT. Incze, Andrea; Chiriac, Carmen Lucia; Kezdi, Iringo Zaharia // Therapeutics, Pharmacology & Clinical Toxicology;2011, Vol. 15 Issue 2, p151 

    Treatment experienced patients had limited treatment options during the past decade. The situation has changed with the arrival of the new antiretrovirals. We describe the case of a human immunodeficiency virus (HIV) infected patient with previous therapeutic failures, low levels of T CD4+ cell...

  • Baseline characteristics, response to and outcome of antiretroviral therapy among patients with HIV-1, HIV-2 and dual infection in Burkina Faso Harries, Katie; Zachariah, Rony; Manzi, Marcel; Firmenich, Peter; Mathela, Richard; Drabo, Joseph; Onadja, G.; Arnould, Line; Harries, Anthony // Transactions of the Royal Society of Tropical Medicine & Hygiene;Feb2010, Vol. 104 Issue 2, p154 

    Summary: In an urban district hospital in Burkina Faso we investigated the relative proportions of HIV-1, HIV-2 and HIV-1/2 among those tested, the baseline sociodemographic and clinical characteristics, and the response to and outcome of antiretroviral therapy (ART). A total of 7368 individuals...

  • Influence of anti-retroviral therapy on the main spheres of vital activity of HIV affected people. Ulyukin, I. M. // Vestnik Sankt-Peterburgskogo universiteta, Seriia 7: Geologia, G;2013, Issue 2, p240 

    134 HIV-infected young adults were examined by using the Russian version of the "World Health Organization Quality of Life Survey (WHOQOL-100)" technique in order to study the influence of the anti-retroviral therapy on the main domains of vital activity of HIV-affected people. The stages of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics