TITLE

ARTERIAL STIFFNESS IN HIV INFECTED PATIENTS

AUTHOR(S)
Papiță¹, Anamaria; Albu², Adriana; Fodor², Daniela; Itu¹, Corina; Cârstina³, D.
PUB. DATE
June 2011
SOURCE
Therapeutics, Pharmacology & Clinical Toxicology;2011, Vol. 15 Issue 2, p111
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Cardiovascular disease is an increasing cause of morbidity and mortality in HIV-infected patients. The increased cardiovascular risk in HIV infected patients is linked to traditional risk factors but also to HIV infection itself which can damage the arterial wall. The antiretroviral treatment (ART) is implicated in metabolic disturbances which can also affect the arterial wall. The aim of our study was to identify the effects of HIV and ART on the aortic artery and the cardiovascular risk by the evaluation of arterial stiffness parameters. Material and methods: A cross-sectional case-control study of 59 HIV-infected patients (55 exposed to ART, 5 ART-naïve) and 40 controls matched by age and sex was performed. Aortic stiffness parameters and brachial parameters were measured using a device called Arteriograf TensioMed attached to a laptop with a TensioMed special software which provided automatic calculations of these markers. Results: HIV-infected patients had a greater aortic pulse wave velocity than the control group (p=0.02) and an increased heart rate (p=0.02). HIV infection and ARV treatment are additional risk factors for rapid onset and progression of atherosclerosis. Conclusions: HIV infection and ARV treatment are associated with increased arterial stiffness and increased heart rate. These vascular alterations are possible causes of the increased cardiovascular risk observed in HIV infected patients.
ACCESSION #
71491910

 

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