Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices

Salazar-Weber, Nina L.; Smith, Jeffrey P.
January 2011
International Journal of Alzheimer's Disease;2011, Vol. 2011, p1
Academic Journal
Copper misregulation has been implicated in the pathological processes underlying deterioration of learning and memory in Alzheimer's disease and other neurodegenerative disorders. Supporting this, inhibition of long-term potentiation (LTP) by copper (II) has been well established, but the exact mechanism is poorly characterized. It is thought that an interaction between copper and postsynaptic NMDA receptors is a major part of the mechanism; however, in this study, we found that copper (II) inhibited NMDA receptor-independent LTP in the CA3 region of hippocampal slices. In addition, in the CA3 and CA1 regions, copper modulated the paired-pulse ratio (PPR) in an LTP-dependent manner. Combined, this suggests the involvement of a presynaptic mechanism in the modulation of synaptic plasticity by copper. Inhibition of the copper-dependent changes in the PPR with cyclothiazide suggested that this may involve an interaction with the presynaptic AMPA receptors that regulate neurotransmitter release.


Related Articles

  • The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors. Lorca, Ramón A.; Varela-Nallar, Lorena; Inestrosa, Nibaldo C.; Huidobro-Toro, J. Pablo // International Journal of Alzheimer's Disease;2011, Vol. 2011, p1 

    Although the physiological function of the cellular prion protein (PrPC) remains unknown, several evidences support the notion of its role in copper homeostasis. PrPC binds Cu2+ through a domain composed by four to five repeats of eight amino acids. Previously, we have shown that the perfusion...

  • Expression of ionotropic glutamate receptors in the retina of the rdta transgenic mouse. Liu, L O; Laabich, A; Hardison, A; Cooper, N G // BMC Neuroscience;2001, Vol. 2, p7 

    Background: The expression of retinal CaMKII is up-regulated in the retina of the rdta mouse in which rod photoreceptors are genetically ablated. As ionotropic glutamate receptors are known substrates of CAMKII, this study set out to determine if the protein levels of ionotropic...

  • Influence of dorsal hippocampal GABA receptors on state-dependent learning induced by CB1 cannabinoid receptors agonist in mice. Jafari, K.; Oryan, Sh.; Pakpour, B.; Navaeian, M.; Piri, M. // Feyz Journal of Kashan University of Medical Sciences;2012, Vol. 16 Issue 4, p288 

    Background: Cannabinoids exert widespread effects on cognitive functions. An overlappeddistribution of GABA receptors and cannabinoid receptors has been reported in some brainstructures (e.g. dorsal hippocampus). Thus, the present study was undertaken to examine the possible role of the dorsal...

  • Localization of Label-Retaining Cells in Murine Vocal Fold Epithelium. Leydon, Ciara; Bartlett, Rebecca S.; Roenneburg, Drew A.; Thibeault, Susan L.; Smith, Anne // Journal of Speech, Language & Hearing Research;Aug2011, Vol. 54 Issue 4, p1060 

    Purpose: Epithelial homeostasis is critical for vocal fold health, yet little is known about the cells that support epithelial self-renewal. As a known characteristic of stem cells is that they are slow-cycling in vivo, the purpose of this prospective controlled study was to identify and...

  • Identification of Candidate Genes Downstream of TLR4 Signaling after Ozone Exposure in Mice: A Role for Heat-Shock Protein 70. Bauer, Alison K.; Rondini, Elizabeth A.; Hummel, Kristin A.; Degraff, Laura M.; Walker, Christopher; Jedlicka, Anne E.; Kleeberger, Steven R. // Environmental Health Perspectives;Aug2011, Vol. 119 Issue 8, p1091 

    BACKGROUND: Toll-like receptor 4 (TLR4) is involved in ozone (O3)-induced pulmonary hyperpermeability and inflammation, although the downstream signaling events are unknown. OBJECTIVES: The aims of our study were to determine the mechanism through which TLR4 modulates O3-induced pulmonary...

  • Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. Tacke, Frank; Alvarez, David; Kaplan, Theodore J.; Jakubzick, Claudia; Spanbroek, Rainer; Llodra, Jaime; Garin, Alexandre; Jianhua Liu; Mack, Matthias; van Rooijen, Nico; Lira, Sergio A.; Habenicht, Andreas J.; Randolph, Gwendalyn J.; Liu, Jianhua // Journal of Clinical Investigation;Jan2007, Vol. 117 Issue 1, p185 

    Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR2(+)CX3CR1(+)Ly-6C(hi) and CCR2(-)CX3CR1(++)Ly-6C(lo) monocytes. Both C-C motif chemokine receptor 2 (CCR2) and C-X(3)-C motif chemokine receptor 1 (CX3CR1) are...

  • Postnatal nutritional restriction affects growth and immune function of piglets with intra-uterine growth restriction. Liang Hu; Yan Liu; Chuan Yan; Xie Peng; Qin Xu; Yue Xuan; Fei Han; Gang Tian; Zhengfeng Fang; Yan Lin; Shengyu Xu; Keying Zhang; Daiwen Chen; De Wu; Lianqiang Che // British Journal of Nutrition;7/17/2015, Vol. 114 Issue 1, p53 

    Postnatal rapid growth by excess intake of nutrients has been associated with an increased susceptibility to diseases in neonates with intrauterine growth restricted (IUGR). The aim of the present study was to determine whether postnatal nutritional restriction could improve intestinal...

  • Beneficial effects of the active principle component of Korean cabbage kimchi via increasing nitric oxide production and suppressing inflammation in the aorta of apoE knockout mice. Noh, Jeong Sook; Choi, Yung Hyun; Song, Yeong Ok // British Journal of Nutrition;Jan2013, Vol. 109 Issue 1, p17 

    The present study investigated the effects of 3′-(4′-hydroxyl-3′,5′-dimethoxyphenyl)propionic acid (HDMPPA), the active principle compound of kimchi, on vascular damage in the experimental atherosclerotic animal. HDMPPA was administrated by an intraperitoneal injection of...

  • Role of TRPV-1 in CGRP-mediated trigeminal sensitization. Chatchaisak, D; Chetsawang, B; le Grand, SM; Govitrapong, P; Srikiatkhachorn, A // Journal of Headache & Pain;Feb2013 Supplement, Vol. 14, p1 

    An abstract of the article "Role of TRPV-1 in CGRP-mediated trigeminal sensitization" by D. Chatchaisak, B. Chetsawang, S. M. Le Grand, P. Govitrapong, and A. Srikiatkhachorn is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics