Independency of acute regulation of IGF-1 system components to growth hormone and insulin in response to resistance exercise

Far, Ehsan Soleymani; Hasani-Ranjbar, Shirin; Heshmat, Ramin; Rajabi, Hamid; Kosari, Hassan
January 2011
Iranian Journal of Diabetes & Lipid Disorders;2011, Vol. 10, p1
Academic Journal
Background: The aim of this study was to determine possible relationship between changes induced by exercise in serum concentrations of growth hormone and insulin with IGF-1 system components over time in trained and untrained individuals. Methods: Nineteen healthy men among physical education students as trained group and 15 healthy men among non-physical education students as untrained group voluntarily participated in this study. The subjects randomly were divided into experimental (trained and untrained) and control (trained and untrained) groups. Blood samples were obtained just before; and at immediately, four and seven hours after the end of exercise. Serum concentrations of GH, Insulin, total IGF-1, IGFBP1 and IGFBP3 were determined. Results: No significant difference was observed in the pre-exercise concentrations of variables between the trained and untrained individuals. However, a strong and positive correlation between areas under curves of variations in IGF-1 and IGFBP3 was identified in the experimental trained group (r=0.872 and p=0.001); and also, there was correlation between areas under curves of variations in Insulin with IGF-1 (r=0.752 and p=0.05) and in IGF-1 with IGFBP3 (r=0.922 and p=0.003) in the control untrained group, but no statistically significant relationship was observed in the control trained and experimental untrained groups. Conclusion: Overall, there was no relationship between acute changes in levels of IGF-1 components with GH and insulin after resistance exercise and the role of each component of the system in mutual regulation of the other components may be more important than nonmember factors of the system during exercise and the following recovery period.


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