Angiogenesis: What's the alternative?

Seton-Rogers, Sarah
February 2012
Nature Reviews Cancer;Feb2012, Vol. 12 Issue 2, p80
Academic Journal
The article presents a study that examines the role of Wilms' tumour suppressor gene (WT1)-mediated regulation of splicing factors on alternative splicing of vascular endothelial growth factor A (VEGFA). It details the method of the study in which the researchers conducted a chromatin immunoprecipitation to identify the link of WT1 and serine/arginine-rich splicing factor 1 (SRSF1). The study indicates that alternative splicing can be an alternative treatment for targeting angiogenesis.


Related Articles

  • SR proteins and galectins: what's in a name? Haudek, Kevin C.; Patterson, Ronald J.; Wang, John L. // Glycobiology;Oct2010, Vol. 20 Issue 10, p1199 

    Although members of the serine (S)- and arginine (R)-rich splicing factor family (SR proteins) were initially purified on the basis of their splicing activity in the nucleus, there is recent documentation that they exhibit carbohydratebinding activity at the cell surface. In contrast, galectins...

  • Identification of a family of DNA-binding proteins with homology to RNA splicing factors. Shipman, Kristy L.; Robinson, Phillip J.; King, Bruce R.; Smith, Roger; Nicholson, Richard C. // Biochemistry & Cell Biology;Feb2006, Vol. 84 Issue 1, p9 

    We describe a unique family of human proteins that are capable of binding to the cAMP regulatory element (CRE) and that are homologous to RNA splicing proteins. A human cDNA was isolated that encodes a protein with a distinctive combination of modular domain structures: 2 leucine-zipper-like...

  • Analysis of the functional specificity of RS domains in vivo. Dauwalder, Brigitte; Mattox, William // EMBO Journal;10/15/98, Vol. 17 Issue 20, p6049 

    A number of splicing factors contain extensive regions that are rich in arginine and serine (RS domains). These domains are thought to facilitate protein—protein interactions that are critical in the regulation of alternative splicing. Using a domain swap strategy, we have tested the...

  • Complementary and Alternative Medical Therapies for Cancer. Sadovsky, Richard // American Family Physician;5/1/2003, Vol. 67 Issue 9, p1991 

    Discusses the study 'Advising Patients Who Seek Complementary and Alternative Medical Therapies for Cancer,' by W.A. Weiger et al., from the December 3, 2002 issue of the journal 'Annals of Internal Medicine.'

  • A deep survey of alternative splicing in grape reveals changes in the splicing machinery related to tissue, stress condition and genotype. Vitulo, Nicola; Forcato, Claudio; Carpinelli, Elisa Corteggiani; Telatin, Andrea; Campagna, Davide; D'Angelo, Michela; Zimbello, Rosanna; Corso, Massimiliano; Vannozzi, Alessandro; Bonghi, Claudio; Lucchin, Margherita; Valle, Giorgio // BMC Plant Biology;2014, Vol. 14 Issue 1, p1 

    Background Alternative splicing (AS) significantly enhances transcriptome complexity. It is differentially regulated in a wide variety of cell types and plays a role in several cellular processes. Here we describe a detailed survey of alternative splicing in grape based on 124 SOLiD RNAseq...

  • A specific SR protein binds preferentially to the secretory protein gene transcripts in salivary glands of Chironomus tentans. Singh, Om Prakash; Visa, Neus; Wieslander, Lars; Daneholt, Bertil // Chromosoma;Dec2006, Vol. 115 Issue 6, p449 

    The members of the serine–arginine (SR) family of proteins play multiple roles in posttranscriptional gene expression. Initially considered as essential splicing factors confined to the nucleus and regulating constitutive and alternative splicing, SR proteins are now known to shuttle...

  • Comparative Analysis of Serine/Arginine-Rich Proteins across 27 Eukaryotes: Insights into Sub-Family Classification and Extent of Alternative Splicing. Richardson, Dale N.; Rogers, Mark F.; Labadorf, Adam; Ben-Hur, Asa; Guo, Hui; Paterson, Andrew H.; Reddy, Anireddy S. N. // PLoS ONE;2011, Vol. 6 Issue 9, p1 

    Alternative splicing (AS) of pre-mRNA is a fundamental molecular process that generates diversity in the transcriptome and proteome of eukaryotic organisms. SR proteins, a family of splicing regulators with one or two RNA recognition motifs (RRMs) at the N-terminus and an arg/ser-rich domain at...

  • Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair. Xiaolong He; Pei Zhang // Molecular Cancer;Aug2015, Vol. 14 Issue 1, p1 

    Background: Our previous work found that serine/arginine-rich splicing factor 3 (SRSF3) was overexpressed in human ovarian cancer and the overexpression of SRSF3 was required for ovarian cancer cell growth and survival. The mechanism underlying the role of SRSF3 in ovarian cancer remains to be...

  • Novel role for a serine/arginine-rich splicing factor, AdRSZ21 in plant defense and HR-like cell death. Kumar, Koppolu; Kirti, P. // Plant Molecular Biology;Nov2012, Vol. 80 Issue 4/5, p461 

    A splicing factor gene belonging to the serine/arginine (SR)-rich protein family was cloned from Arachis diogoi, a wild relative of peanut in a study on differential gene expression and was designated as AdRSZ21. AdRSZ21 exhibits a RNA recognition motif (RRM), a CCHC type zinc finger domain...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics