Grapefruit juice: potential drug interactions

Maskalyk, James
August 2002
CMAJ: Canadian Medical Association Journal;8/6/2002, Vol. 167 Issue 3, p279
Academic Journal
Reports on potential drug interactions with grapefruit juice. How a substrate contained in the juice binds to the intestinal isoenzyme causing a sustained decrease in CYP3A4 protein expression; Inhibition of the drug metabolism in the intestine; Unknown chemical compound in grapefruit that causes the interaction.


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