Adiponectin and sE-selectin Concentrations in Relation to Inflammation in Obese Type 2 Diabetic Patients With Coronary Heart Disease

El-Mesallamy, Hala O.; Hamdy, Nadia M.; Salman, Tarek M.; Ibrahim, Sherine M.
April 2012
Angiology;Apr2012, Vol. 63 Issue 2, p96
Academic Journal
Adipose tissue can release proinflammatory mediators, namely C-reactive protein (CRP), interleukin 1β (IL-1β), and monocyte chemotactic protein 1 (MCP-1), contributing to vascular injury and insulin resistance (IR). Other mediators namely, adiponectin and nitric oxide (NO) are protective. We enrolled type 2 diabetes mellitus (T2DM) obese male patients without coronary heart disease ([CHD] group II, n = 25) and T2DM obese patients with CHD (group III, n = 25). They were compared with 20 age- and body mass index (BMI)-matched nondiabetic control males (group I). Fasting blood glucose (FBG), glycated hemoglobin (HbA1c%), lipids, insulin, malondialdehyde ([MDA]; lipid peroxidation product), NO, high-sensitivity CRP (hsCRP), IL-1β, MCP-1, adiponectin as well as sE-selectin concentration were significantly different in patients with T2DM and CHD compared with patients without CHD and nondiabetic controls (P = .01). There was a significant negative correlation between adiponectin and E-selectin (P = .0001). Adipose tissue in T2DM obese patients may contribute to the pathogenesis of CHD.


Related Articles

  • Postprandial interleukin-6 response in elderly with abdominal obesity and metabolic syndrome. Moreira, P.; Dalboni, M.; Cendoroglo, M.; Santos, G.; Cendoroglo, Maysa // Journal of Nutrition, Health & Aging;Mar2013, Vol. 17 Issue 3, p206 

    Objective: The aim of this study is to evaluate the contribution of central obesity to inflammatory responses in the postprandial state in elderly patients with and without metabolic syndrome (MetS). Material/Methods: We evaluated 80 elderly individuals who were distributed into three groups:...

  • Stronger Correlation between Interleukin 18 and Soluble Fas in Lupus Nephritis Compared with Mild Lupus. Hatef, Mohammad Reza; Sahebari, Maryam; Rezaieyazdi, Zahra; Nakhjavani, Mohammad Reza; Mahmoudi, Mahmoud // ISRN Rheumatology;2013, p1 

    Lupus nephritis (LN) is a major cause of morbidity in patients with systemic lupus erythematosus (SLE). Several cytokines and apoptotic markers such as IL-18 and soluble Fas (sFas) have been assumed to play a role in the pathogenesis of LN. Previous studies confirmed that serum concentrations of...

  • Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans? Lee, P.; Linderman, J.; Smith, S.; Brychta, R. J.; Perron, R.; Idelson, C.; Werner, C. D.; Chen, K. Y.; Celi, F. S. // Osteoporosis International;Dec2013, Vol. 24 Issue 12, p3053 

    Summary: In animals, high fibroblast growth factor 21 (FGF21) states improve insulin resistance but induce bone loss. Whether FGF21 relates to bone mineral density (BMD) is unknown in humans. Contrary to prediction from animal findings, we found higher FGF21 levels associating with greater BMD...

  • Obesity, Inflammation and Acute Myocardial Infarction--Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population. Rajendran, Karthick; Devarajan, Nalini; Ganesan, Manohar; Ragunathan, Malathi // Thrombosis Journal;2012, Vol. 10 Issue 1, p13 

    Background: Obesity, characterised by increased fat mass and is currently regarded as a pro-inflammatory state and often associated with increased risk of cardiovascular diseases (CVD) including Myocardial infarction. There is an upregulation of inflammatory markers such as interleukin-6,...

  • Galectin-3 and Plasma Cytokines in Patients With Acute Myocardial Infarction. Alturfan, A. Ata; Basar, Isık; Emekli-Alturfan, Ebru; Ayan, Faruk; Koldas, Lale; Emekli, Nesrin // Laboratory Medicine;Fall2014, Vol. 45 Issue 4, p336 

    Objective: To investigate the concentrations of plasma cytokines and Galectin-3 (Gal-3) as inflammatory markers in patients with acute myocardial infarction (AMI). Methods: The study population consisted of 29 patients with AMI and 29 healthy control subjects. We measured Gal-3, tumor necrosis...

  • Endocan—A Novel Inflammatory Indicator in Newly Diagnosed Patients With Hypertension: A Pilot Study. Balta, Sevket; Mikhailidis, Dimitri P.; Demirkol, Sait; Ozturk, Cengiz; Kurtoglu, Ertugrul; Demir, Mustafa; Celik, Turgay; Turker, Turker; Iyisoy, Atila // Angiology;Oct2014, Vol. 65 Issue 9, p773 

    Endothelial dysfunction is regarded as the initial lesion in the development of atherosclerosis. Endocan, previously called endothelial cell–specific molecule 1 (ESM-1), is a new candidate immunoinflammatory marker that may be associated with cardiometabolic risk factors. Therefore, we...

  • The association of ghrelin -501A/C polymorphism with ghrelin and leptin levels in non-obese Saudi Population with type 2 diabetes mellitus. Ali, Tarek Mohamed; Khalifa, Amany Salah; Ali, Mohamed Noureldin H. // National Journal of Physiology, Pharmacy & Pharmacology;2015, Vol. 5 Issue 3, p243 

    Background: Saudi Arabia is one of the three of the world's top 10 countries with the highest prevalence of diabetes mellitus. Ghrelin is a gut-brain endogenous peptide, and the genetic variations within the gene have been associated with the risk of developing type 2 diabetes mellitus (T2DM)....

  • Time course of inflammatory cytokines in acute ischemic stroke patients and their relation to inter-alfa trypsin inhibitor heavy chain 4 and outcome. Nayak, Amit R.; Kashyap, Rajpal S.; Kabra, Dinesh; Purohit, Hemant J.; Taori, Girdhar M.; Daginawala, Hatim F. // Annals of Indian Academy of Neurology;Sep2012, Vol. 15 Issue 3, p181 

    Background: Biomarker for prognosis of stroke is urgently needed for the management of acute ischemic stroke (AIS) patients. Objective: To evaluate the course of inflammatory cytokines in AIS patients and its comparison with inter-alfa trypsin inhibitor heavy chain 4 (ITIH4) and outcome after...

  • Ä°stanbul'da Bir EÄŸitim ve AraÅŸtırma Hastanesine BaÅŸvuran Hastalarda Hepatit A Seroprevalansı. ALICI, Özlem; AĞALAR, Canan; YAZICILAR, Hanife Aydın // Viral Hepatitis Journal / Viral Hepatit Dergisi;Dec2013, Vol. 19 Issue 3, p110 

    Objective: Hepatitis A virus (HAV) is the etiologic agent of an enterically transmitted viral hepatitis associated with poor environmental hygienic conditions. HAV is endemic in developing countries including Turkey and most of the HAV infections occur during early childhood in such countries....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics