TITLE

LA DEPLECION DE LAS CELULAS T REGULATORIAS AUMENTA EL NUMERO DE LAS CELULAS CD8 DURANTE LA INFECCION CON EL VIRUS DEL TUMOR MAMARIO MURINO

AUTHOR(S)
Cabrera, Gabriel; Mundiñano, Juliana; Camicia, Gabriela; Costa, Hector; Nepomnaschy, Irene; Piazzon, Isabel
PUB. DATE
June 2011
SOURCE
Medicina (Buenos Aires);2011, Vol. 71 Issue 3, p243
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. We have shown in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen (Sag)-specific CD4+ CD25+ Foxp3+ regulatory T cells (Treg) in Peyer's patches. Herein, we evaluated whether the depletion of Treg cells affects the CD8+ population during milk-borne MMTV infection. At day 6 of infection, the depletion of Treg cells increased the percentage and absolute number of CD8+ cells in lymph nodes as well as the mean intensity fluorescence of the CD44 activation marker. The absolute number of CD8+ cells was increased in cells bearing both Sag reactive and non-reactive TCR Vβ chains. We have previously shown that regulatory T cell depletion at day 6 of infection decrease viral load. Results reported herein suggest that at least after day 6 of MMTV infection Treg cells play an inhibiting role on CD8 antiviral response.
ACCESSION #
70340921

 

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