TITLE

HIPERTENSION ARTERIAL COMO FACTOR PREDICTIVO EN PACIENTES CON CANCER RENAL TRATADOS CON ANTIANGIOGENICOS

AUTHOR(S)
Gennari, Luciana; Belinky, Javier; Graziano, Claudio; Jankilevich, Gustavo
PUB. DATE
June 2011
SOURCE
Medicina (Buenos Aires);2011, Vol. 71 Issue 3, p207
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Knowledge of several pathways of oncogenesis has led to the development of novel therapies in the treatment of advanced kidney cancer in the last five years. These have targeted the vascular endothelium-derived factor (VEGF) (angiogenesis) and mammalian target of rapamycin (mTOR). Antiangiogenics are a group of active molecules with a peculiar spectrum of toxicity including the development of hypertension, thyroid dysfunction and hand-foot syndrome. The identification of molecular and clinical predictors would allow to identify those patients who would benefit from such treatment and saveguarding the rest from toxic exposure. The occurrence of hypertension has been correlated with treatment response and clinical efficacy. In our retrospective series, patients treated with antiangiogenic agents who developed high blood pressure showed a higher response rate and disease-free interval compared to those without increased blood pressure. Hypertension should be considered a clinical predictor in the treatment of these patients. These findings should be confirmed in a larger study population.
ACCESSION #
70340915

 

Related Articles

  • Sunitinib.  // Reactions Weekly;8/22/2009, Issue 1266, p30 

    The article describes the case of a woman who developed hypertension after receiving oral sunitinib due renal artery stenosis. The woman has undergone right nephrectomy for renal cancer. Two weeks after receiving the treatment, her blood pressure (BP) increased. She was given manidipine and...

  • What Was Normal Blood Pressure Is Now Considered Too High.  // Tufts University Health & Nutrition Letter;Jul2003, Vol. 21 Issue 5, p4 

    Reports on the introduction of the prehypertension category in the blood pressure guidelines of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure in the U.S., as of July 2003. Prevalence of prehypertension in the U.S.; Lifestyle changes...

  • Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase. Sarr, Mamadou; Chataigneau, Marta; Martins, Sandrine; Schott, Christa; El Bedoui, Jasser; Oak, Min-Ho; Muller, Bernard; Chataigneau, Thierry; Schini-Kerth, Val�rie B. // Cardiovascular Research;Sep2006, Vol. 71 Issue 4, p794 

    Abstract: Objective: Chronic administration of moderate amounts of red wine has been associated with a protective effect on the cardiovascular system. This study examined whether red wine polyphenols prevent the angiotensin II (Ang II)-induced hypertension and endothelial dysfunction in rats,...

  • Chapter 1: What is High Blood Pressure? Gregson, Susan R. // High Blood Pressure (Capstone Press);2001, p4 

    This chapter describes high blood pressure. Blood pressure is the force of your blood on the walls of your arteries. When blood pressure stays high for too long, it can damage your blood vessels. There are two numbers used in measuring blood pressure. The first number records systolic pressure,...

  • Chapter 6: Looking Ahead. Gregson, Susan R. // High Blood Pressure (Capstone Press);2001, p52 

    This chapter looks at the advances and research in fighting high blood pressure. Controlling blood pressure now can reduce the effects of physical deterioration later in life. Researchers have identified the 'salt gene' which can help doctors predict how well you will respond to lifestyle...

  • Hypertension -- Noninvasive Testing.  // Current Medical Literature: Nephrology & Hypertension;2006, Vol. 12 Issue 4, p132 

    The article presents an abstract of the research "How long shall the patient rest before clinic blood pressure measurement?," by C. Sala and colleagues, published in the 2006 issue of the "American Journal of Hypertension." In the study, researchers monitored the changes in the arterial blood...

  • Here's the lowdown on high blood pressure. Bennett, Lydia // New Hampshire Business Review;4/19/2002, Vol. 24 Issue 8, p9B 

    Discusses how to deal with high blood pressure. Causes of hypertension; Risks associated with hypertension; Details of how to avoid complications.

  • Marily Rhudy to receive Jacob W. Miller Award.  // Pharmacy Today;Mar2006, Vol. 12 Issue 3, p24 

    The article reports that a study of community pharmacy-based hypertension interventions manifests that pharmacists can do much to help patients control their blood pressure. The large number of patients attended in the Hypertension Outcomes through blood pressure Monitoring and Evaluation by...

  • Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension. M Oddo // Journal of Neurology, Neurosurgery & Psychiatry;Aug2009, Vol. 80 Issue 8, p916 

    BACKGROUND: The impact of osmotic therapies on brain oxygen has not been extensively studied in humans. We examined the effects on brain tissue oxygen tension (PbtO2) of mannitol and hypertonic saline (HTS) in patients with severe traumatic brain injury (TBI) and refractory intracranial...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics