Warfarin testing every 12 weeks?

January 2012
Travel Medicine Advisor;Jan2012 Supplement, p1
The article reports on the result of a study which examines the interval for prothrombin time monitoring for warfarin. The study utilizes 226 patients who were on a stable dose of warfarin for 6 months and were assigned to testing every 4 weeks and every 12 weeks. It shows that the 12-week group manifested fewer dose changes and secondary outcomes such as major bleeding, thromboembolism and death.


Related Articles

  • Warfarin and intracranial hemorrhage. Hylek, EM; Singer, DE // Patient Care;9/30/1994, Vol. 28 Issue 15, p102 

    Reports that a prothrombin time ratio (PTR) of less than 2.0 is essential in patients taking warfarin. Findings of researchers at the Massachusetts General Hospital; Description of the study group; Risk of intracerebral hemorrhage; Predictors of intracerebral hemorrhage.

  • Quinidine-Induced Hypoprothrombinemic Hemorrhage in Patients on chronic Warfarin Therapy. Koch-Weser, Jan // Annals of Internal Medicine;Mar68, Vol. 68 Issue 3, p411 

    Presents case reports on the development of hypoprothrombinemia and hemorrhage due to the institution of quinidine. Manifestations of the disease; Diagnosis of patients; Interaction between quinidine and warfarin.

  • Tamoxifen.  // Reactions Weekly;6/21/2008, Issue 1207, p32 

    The article describes the case of a 25-year-old man who developed venous thromboembolism while receiving tamoxifen for oligozoospermia. The man presented with progressive shortness of breath, haemoptysis and pleuritic chest pain. He was treated with heparin. His chest pain and haemoptysis...

  • Dabigatran: An Oral Direct Thrombin Inhibitor. Elliott, William T. // Clinical Cardiology Alert;Feb2010 Supplement 2, p1 

    The article discusses results from a Phase 3 study of oral direct thrombin inhibitor dabigatran. This drug is being used as an alternative to warfarin, but does not require monitoring with blood tests. Warfarin is effective in the prevention of stroke in patients with atrial fibrillation. These...

  • A sensitivity comparison of the Quick and Owren prothrombin time methods in oral anticoagulant therapy. Horsti, Juha // Hematology Reviews;2009, Vol. 1 Issue 2, p87 

    Prothrombin time (PT) is the leading test for monitoring oral anticoagulation therapy (OAT). According to the World Health Organization recommendation, International Normalized Ratio (INR) results obtained from the same patient samples with the major PT methods (Quick and Owren) should be the...

  • Clinical: Haematology - Reversal of warfarin treatment. Patel, Shruthi; Hanley, John // GP: General Practitioner;9/16/2011, p42 

    The article offers information on the reversal of warfarin treatment, whose only side-effect is bleeding. It states that patients receiving warfarin should be monitored, with regular checks of international normalized ratio (INR). It mentions that warfarin can be reversed by the administration...

  • Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate. Brodsky, Sergey V.; Nadasdy, Tibor; Rovin, Brad H.; Satoskar, Anjali A.; Nadasdy, Gyongyi M.; Wu, Haifeng M.; Bhatt, Udayan Y.; Hebert, Lee A. // Kidney International;Jul2011, Vol. 80 Issue 2, p181 

    An acute increase in the international normalized ratio (INR; a comparison of prothrombin time to monitor the effects of warfarin) over 3 in patients with chronic kidney disease (CKD) is often associated with an unexplained acute increase in serum creatinine (SC) and an accelerated progression...

  • Rapid reversal of coagulopathy in warfarin-related intracranial haemorrhages with prothrombin complex concentrates. CHONG, C. T.; LEW, T. W. K.; KUPERAN, P.; TAN, J. J. E.; TAN, H. L.; KWEK, T. K. // Anaesthesia & Intensive Care;May2010, Vol. 38 Issue 3, p474 

    The article discusses the role of Profilnine SD, a 3-Factor prothrombin complex concentrate (PCC), on the rapid reversal of coagulopathy in patients presenting with warfarin-related intracerebral hemorrhage. The use of PCC should be considered for the urgent reversal of international normalized...

  • Warfarin interaction.  // Reactions Weekly;2/25/2006, Issue 1090, p25 

    Presents a case report on interaction with concomitant oxandrolone leading to prothrombin time elevation and hemorrhage in a 93-year-old woman who was receiving warfarin for atrial fibrillation. Reason for the patient to receive oxandrolone; Increase in the prothrombin time of the patient after...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics