TITLE

Absence of TLR4 Asp299Gly and Thr399Ile Polymorphisms in Chinese Han Population With Type 2 Diabetes

AUTHOR(S)
Peng-bin Lai; Lei Zhang; Sun-jie Yan; Li-yong Yang
PUB. DATE
September 2010
SOURCE
Laboratory Medicine;Sep2010, Vol. 41 Issue 9, p559
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: This study was performed to detect the association between the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene and type 2 diabetes in the Chinese Han population. Methods: The study included 856 unrelated individuals with type 2 diabetes and 672 healthy controls. The polymorphisms of the TLR4 gene were examined through denaturing high-performance liquid chromatography. Results: Neither the Asp299Gly nor the Thr399Ile polymorphism was detected in any of the diabetic and healthy subjects. Conclusions: Our finding indicates the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene are very rare in the Chinese Han population.
ACCESSION #
70267958

 

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