TITLE

Molecular Epidemiology and Drug Susceptibility of Pseudomonas aeruginosa Strains Isolated From Burn Patients

AUTHOR(S)
Salimi, Hassan; Yakhchali, Bagher; Owlia, Parviz; Lari, Abdolaziz Rastegar
PUB. DATE
September 2010
SOURCE
Laboratory Medicine;Sep2010, Vol. 41 Issue 9, p540
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Pseudomonas aeruginosa is 1 of the major agents of nosocomial infections in burn centers. Our objectives were to determine the genetic diversity of P. aeruginosa isolated from burn patients. Methods: One hundred thirty-one P. aeruginosa isolates were collected from the burn center of Shahid Motahhari Hospital in Tehran. Phenotypic screening for drug susceptibility was performed by disk diffusion method according to Clinical Laboratory Standards Institute guidelines, and genetic diversity of all isolates was determined by the pulsed-field gel electrophoresis (PFGE) technique. Results: Antimicrobial susceptibility testing showed that the majority of P. aeruginosa strains were resistant to ceftizoxime (87%) and aztreonam (80.2%). Pulsed-field gel electrophoresis revealed 11 profiles in which environmental strains were included in PFGE1 and PFGE7 patterns. The major PFGE profile was PFGE1 containing 18 (42.9%) MDR isolates and including an environmental MDR bacterium. Conclusions: Our findings highlighted that further attention needs to be focused on the disinfection of this burn unit.
ACCESSION #
70267955

 

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